ArticleEndocrinology and metabolism (Seoul, Korea)2017
The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus.
Article in Endocrinology and metabolism (Seoul, Korea), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling.Andrology · 2026Article
- Energy's long game: thermogenic adipocytes and the metabolic diseases of modern life.Academia biology · 2026Article
- Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases.Biomedicines · 2024Review
- The integrated bioinformatic analysis identifies immune microenvironment-related potential biomarkers for patients with gestational diabetes mellitus.Frontiers in immunology · 2024Article
- New players of the adipose secretome: Therapeutic opportunities and challenges.Current opinion in pharmacology · 2022Review
- Serum CD14 concentration is associated with obesity and insulin resistance in non-diabetic individuals.The Journal of international medical research · 2022Article
- The Heartwarming Effect of Brown Adipose Tissue.Molecular pharmacology · 2022Review
- The Role of Slit-2 in Gestational Diabetes Mellitus and Its Effect on Pregnancy Outcome.Frontiers in endocrinology · 2022Article
- Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential.International journal of molecular sciences · 2021Review
- The relevance of plasma R-spondin 1 and Slit2 as predictive biomarkers in cervical cancer chemotherapy and radiotherapy.Annals of translational medicine · 2021Article
- Development of a Cell-Based Assay for the Detection of Neutralizing Antibodies to PF-06730512 Using Homogenous Time-Resolved Fluorescence.The AAPS journal · 2020Article
- Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism.Endocrine reviews · 2020Review
- Deletion of Robo4 prevents high-fat diet-induced adipose artery and systemic metabolic dysfunction.Microcirculation (New York, N.Y. : 1994) · 2019Article
- Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs.Journal of clinical medicine · 2019Review
- Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance.Diabetes & metabolism journal · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSlit2 is a new secreted protein from adipose tissue that improves glucose hemostasis in mice; however, there is no study about the serum levels and precise role of Slit2 in human. The aim of this study is to explore the serum level of Slit2 in human, and to identify the role of Slit2 in diabetes mellitus (DM).
methodsThe participants of this study consist of 38 subjects with newly diagnosed DM, and 75 healthy subjects as a control group. Serum Slit2 levels were measured using an enzyme-linked immunosorbent assay. Relationship between circulating Slit2 and diabetic related factors was investigated in diabetic group compared with non-diabetic group. Additionally, the correlations between the serum level of Slit2 and diverse metabolic parameters were analyzed.
resultsCirculating Slit2 level was more decreased in diabetic group than in control group, but there was no significant difference statistically. Interestingly, serum levels of Slit2 were significantly negatively correlated to the serum concentrations of fasting glucose (coefficient r=-0.246, P=0.008), the serum concentrations of postprandial glucose (coefficient r=-0.233, P=0.017), and glycosylated hemoglobin (HbA1c; coefficient r=-0.357, P<0.001).
conclusionFrom our study, the first report of circulating Slit2 levels in human, circulating Slit2 level significantly negatively correlated with serum glucose and HbA1c. Our results suggest that the circulating Slit2 may play a role in maintainence of glucose homeostasis in human, even though exact contribution and mechanism are not yet known.
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