Evidence map›Paper›PMID 28956265›Full record

ArticleMolecular imaging and biology2018

In vivo Biodistribution of Radiolabeled Acoustic Protein Nanostructures.

Johann Le Floc'h, Aimen Zlitni, Holly A Bilton, Melissa Yin, Arash Farhadi, Nancy R Janzen, Mikhail G Shapiro, John F Valliant, F Stuart Foster

Abstract read
In one paragraph

Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Truly Tiny Acoustic Biomolecules for Ultrasound Imaging and Therapy.Advanced materials (Deerfield Beach, Fla.) · 2024
    Article
  3. Truly tiny acoustic biomolecules for ultrasound imaging and therapy.bioRxiv : the preprint server for biology · 2023
    Article
  4. Modification of PEG reduces the immunogenicity of biosynthetic gas vesicles.Frontiers in bioengineering and biotechnology · 2023
    Article
  5. Article
  6. Article
  7. Non-Modified Ultrasound-Responsive Gas Vesicles fromInternational journal of nanomedicine · 2021
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johann Le Floc'hSunnybrook Research Institute, 2075 Bayview Avenue, Room S640, Toronto, ON, M4N 3M5, Canada. jlefloch@sri.utoronto.ca.ORCID 0000-0003-0010-5120
Aimen ZlitniDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S4L8, Canada.
Holly A BiltonDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S4L8, Canada.
Melissa YinSunnybrook Research Institute, 2075 Bayview Avenue, Room S640, Toronto, ON, M4N 3M5, Canada.
Arash FarhadiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Nancy R JanzenDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S4L8, Canada.
Mikhail G ShapiroDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
John F ValliantDepartment of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S4L8, Canada. valliant@mcmaster.ca.
F Stuart FosterSunnybrook Research Institute, 2075 Bayview Avenue, Room S640, Toronto, ON, M4N 3M5, Canada.

Funding

Biogenic Gas Nanostructures As Molecular Imaging Reporters For UltrasoundR01EB018975 · NIBIB · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Mikhail Shapiro · 2014 to 2026
$5.9M
Canadian Cancer Society 2015:703857CIHR 2016: 493840-16CIHR MOP136842NIBIB NIH HHS R01 EB018975NIH HHS 1R01EB018975
6 · The paper itself

Abstract

purposeContrast-enhanced ultrasound plays an expanding role in oncology, but its applicability to molecular imaging is hindered by a lack of nanoscale contrast agents that can reach targets outside the vasculature. Gas vesicles (GVs)-a unique class of gas-filled protein nanostructures-have recently been introduced as a promising new class of ultrasound contrast agents that can potentially access the extravascular space and be modified for molecular targeting. The purpose of the present study is to determine the quantitative biodistribution of GVs, which is critical for their development as imaging agents. PROCEDURES: We use a novel bioorthogonal radiolabeling strategy to prepare technetium-99m-radiolabeled ([

resultsTwenty minutes following administration to mice, the SPECT biodistribution shows that 84 % of [

conclusionsThese results provide essential information for the development of GVs as targeted nanoscale imaging agents for ultrasound.

Indexed as

AcousticsAnimalsFemaleFluorescenceImaging, Three-DimensionalLiverMiceNanostructuresProteinsRadiopharmaceuticalsSpleenTechnetiumTissue DistributionTomography, Emission-Computed, Single-PhotonProteinsRadiopharmaceuticalsTechnetiumAcoustic nanostructuresBiodistributionBioorthogonal chemistryGas vesiclesSPECT/CTTechnetium-99mUltrasound contrast agent

Identifiers

PMID28956265
PMCPMC6110388

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.