ArticleInternational urology and nephrology2017
Predictive value of procalcitonin for diagnosis of infections in patients with chronic kidney disease: a comparison with traditional inflammatory markers C-reactive protein, white blood cell count, and neutrophil percentage.
Article in International urology and nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Diagnostic value of procalcitonin for bacterial infections in patients undergoing hemodialysis: a systematic review and meta-analysis.Renal failure · 2022Pooled it
- Marked Non-Infectious Elevation of Procalcitonin in a Hemodialysis Patient with Bladder Cancer: A Case Report.Infection and drug resistance · 2026Article
- Investigating the Effects of Metabolic and Bariatric Surgery on Systemic Immune-Inflammation Index and Its Relationship With Smoking.World journal of surgery · 2025Observational
- Changes of Procalcitonin Kinetics According to Renal Clearance in Critically Ill Patients with Primary Gram-Negative Bloodstream Infections.Infectious diseases & clinical microbiology · 2024Article
- Article
- The Sustained and Marked Elevation of Serum Procalcitonin in a Hemodialysis Patient with Tuberculous Lymphadenitis, but Without the Evidence of Sepsis: A Case Report.Infection and drug resistance · 2022Article
- Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018.Frontiers in endocrinology · 2022Article
- Effect of clinical factors on trajectory of functional performance in patients undergoing hemodialysis.Renal failure · 2021Observational
- Increased neutrophil percentage-to-albumin ratio is associated with all-cause mortality in patients with severe sepsis or septic shock.Epidemiology and infection · 2020Article
- Elevated serum procalcitonin level in patients with chronic kidney disease without infection: A case-control study.Journal of clinical laboratory analysis · 2020Article
- Predictive value of procalcitonin in chronic allograft dysfunction in kidney transplant recipients.Experimental and therapeutic medicine · 2019Article
- Prognostic significance of PCT and CRP evaluation for adult ICU patients with sepsis and septic shock: retrospective analysis of 59 cases.The Journal of international medical research · 2019Article
- Biological variation of procalcitonin levels in hemodialysis patients.Clinical and experimental nephrology · 2019Article
- Biochemical indicators, physical activity, and functional performance in elderly CKD patients: A cross-sectional study.Science progressArticle
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the predictive value of procalcitonin (PCT) in patients with stage 1-4 and stage 5 chronic kidney disease (CKD).
methodsFive hundred and forty-one CKD inpatients were retrospectively analyzed and divided into CKD stage 1-4 (CKD1-4) and CKD stage 5 (CKD5) groups. Each group was further divided into non-infection, local infection, and sepsis subgroups. The clinical characteristics and inflammatory indexes of each subgroup including PCT, C-reactive protein (CRP), white blood cell count (WBC), and neutrophil percentage (N%) were compared, and the receiver operating characteristic curves to predict local infection and sepsis were plotted.
resultsOur research showed that the incidence and severity of infection in CKD5 group were significantly higher than those of CKD1-4 group; the baseline PCT level in CKD patients increased as renal function decreased and strongly correlated with CKD staging (r = 0.749); for CKD1-4 group, PCT, WBC, and N% could predict sepsis with the area under the curve (AUC) of 0.956, 0.854, and 0.917, respectively, but only CRP could predict local infection with AUC of 0.729, and for CKD5 group, only PCT and CRP could predict local infection with AUC of 0.715 and 0.780, respectively, and only PCT and N% could predict sepsis with AUC of 0.823 and 0.683, respectively.
conclusionsThe baseline PCT level of CKD patients is negatively correlated with renal function. In both CKD1-4 and CKD5 patients, the predictive value of PCT for local infection is not as good as that of CRP, while it has a significant advantage in predicting sepsis.
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