ArticleJournal of materials science. Materials in medicine2017
Investigating the performance of drug delivery system of fluconazole made of nano-micro fibers coated on cotton/polyester fabric.
Article in Journal of materials science. Materials in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 25 citations in OpenAlex.
- Optimisation of electrospinning parameters to successfully obtain high ratios of medium chain length polyhydroxyalkanoate in electrospun fibres with drug loading for wound healing applications.Journal of materials science. Materials in medicine · 2026Article
- Highly Durable Antibacterial Textiles: Cross-Linked Protonated Polyaniline-Polyacrylic Acid with Prolonged Electrical Stability.ACS omega · 2024Article
- Investigating the Synthesis and Characterization of a Novel "Green" H₂O₂-Assisted, Water-Soluble Chitosan/Polyvinyl Alcohol Nanofiber for Environmental End Uses.Nanomaterials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymer-based drug delivery systems are suitable to optimize the therapeutic properties of drugs and to render them safer, more effective and reliable. Long-term or repeated use of oral administration of fluconazole for treating chronic candidiasis in the patient and partially abandoned treatment lead to the resistant strains of the fungus Candida albicans and severity of the disease. In this study, the use of nanofibers and microfibers containing fluconazole for local drug delivery to increase the efficiencies and reduce the side effects caused by taking the drug was studied. Morphology, microstructure and chemical composition of PVA nanofibers containing fluconazole were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). As well as, the DSC test was indicated presence of fluconazole in PVA fibrous mats. The rate of drug release was investigated by UV-Vis spectrophotometery and swelling technique. SEM images showed that the nanofibers with uniform structure without beads were produced. The mechanical properties of the pristine PVA nanofiber and fibrous mat containing drug were evaluated. The release of fluconazole from PVA nanofibers in pH of 7.4 and at 37 °C was investigated. The results presented that the drug release rate is dependent on the morphology and structure of PVA nanofibers and could be adjusted in desired dosage. The presented products are applicable in the high production form for medical textile industry.
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Registered trials
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