Evidence map›Paper›PMID 28956184›Full record

ArticleNeurosurgical review2018

Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.

Manabu Natsumeda, Kunio Motohashi, Hironaka Igarashi, Takanori Nozawa, Hideaki Abe, Yoshihiro Tsukamoto, Ryosuke Ogura, Masayasu Okada, Tsutomu Kobayashi, Hiroshi Aoki and 5 more

Abstract read
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In one paragraph

Article in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  11. Magnetic resonance spectroscopy for the study of cns malignancies.Progress in nuclear magnetic resonance spectroscopy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Manabu NatsumedaDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.ORCID http://orcid.org/0000-0003-3098-8323
Kunio MotohashiDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Hironaka IgarashiCenter for Integrated Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan. higara@bri.niigata-u.ac.jp.
Takanori NozawaDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Hideaki AbeDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Yoshihiro TsukamotoDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Ryosuke OguraDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Masayasu OkadaDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Tsutomu KobayashiDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Hiroshi AokiDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Hitoshi TakahashiDepartment of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan.
Kouichirou OkamotoDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Tsutomu NakadaCenter for Integrated Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Yukihiko FujiiDepartment of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan.
Niigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously reported that reliable detection of 2-hydroxyglutarate (2HG) in isocitrate dehydrogenase (IDH)-mutant WHO grade 2 and 3 gliomas is possible utilizing 3.0-T single-voxel magnetic resonance spectroscopy (SVMRS). We set out to determine whether the same method could be applied to detect 2HG in IDH-mutant glioblastoma. Forty-four patients harboring glioblastoma underwent pre-operative MRS evaluation to detect 2HG and other metabolites. Presence of IDH-mutations was determined by IDH1 R132H immunohistochemical analysis and DNA sequencing of surgically obtained tissues. Six out of 44 (13.6%) glioblastomas were IDH-mutant. IDH-mutant glioblastoma exhibited significantly higher accumulation of 2HG (median 3.191 vs. 0.000 mM, p < 0.0001, Mann-Whitney test). A cutoff of 2HG = 0.897 mM achieved high sensitivity (100.0%) and specificity (92.59%) in determining IDH-mutation in glioblastoma. Glioblastoma with high 2HG accumulation did not have significantly longer overall survival than glioblastoma with low 2HG accumulation (p = 0.107, log-rank test). Non-invasive and reliable detection of 2HG in IDH-mutant glioblastoma was possible by 3.0-T SVMRS.

Indexed as

Magnetic Resonance SpectroscopyAdolescentAdultAgedAged, 80 and overBrain NeoplasmsChildFemaleGlioblastomaGlutaratesHumansIsocitrate DehydrogenaseMaleMiddle AgedMutationReproducibility of Resultsalpha-hydroxyglutarateGlutaratesIsocitrate Dehydrogenase2-HydroxyglutarateGlioblastomaIDH mutationMagnetic resonance spectroscopy

Identifiers

PMID28956184
OpenAlexW2759960503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.