Evidence map›Paper›PMID 28956153›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2018

Predictors of survival stratification in patients with wild-type cardiac amyloidosis.

F Aus dem Siepen, R Bauer, A Voss, S Hein, M Aurich, J Riffel, D Mereles, C Röcken, S J Buss, H A Katus and 1 more

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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  6. Review
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  9. Liver stiffness as a prognostic parameter and tool for risk stratification in advanced cardiac transthyretin amyloidosis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
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  19. Review
  20. Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis.Journal of cardiovascular development and disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

F Aus dem SiepenDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
R BauerDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
A VossDepartment of Psychology, University of Heidelberg, Heidelberg, Germany.
S HeinDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
M AurichDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
J RiffelDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
D MerelesDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
C RöckenInstitute of Pathology, Christian-Albrechts-University, Arnold-Heller-Straße 3/14, 24105, Kiel, Germany.
S J BussDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
H A KatusDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Arnt V KristenDepartment of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Arnt.Kristen@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-7657-3700
Heidelberg University · DEChristian-Albrechts-Universität zu Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze clinical predictors of mortality in wild-type transthyretin amyloidosis (wt-ATTR).

methodsIn total, 191 patients (73.8 ± 0.5 years; 176 males, 15 females) with histologically proven wt-ATTR amyloidosis and genetic exclusion of a transthyretin gene variant were included. Comprehensive clinical characteristics, ECG, biomarkers, and echocardiography were analyzed retrospectively. Strain analyses were performed offline using TomTec Imaging Systems, Germany. Univariable and multivariable analyses predicting all-cause mortality were carried out.

resultsPatients presented with significant heart failure (NYHA 2.5 ± 0.8; NT-proBNP 3644 (4981) pg/ml; LV ejection fraction 45.8 ± 15.0%). LogNT-proBNP correlated with indicators of disease severity. Similar results were obtained for basal and midventricular, but not apical longitudinal strain. During median follow-up of 26.2 ± 1.7 months 46 (25.5%) patients died (40 males, 23%; six females, 40%). In female patients 1-/2-year survival was lower [92.9/67.7%; median survival 30.6 (21.1-40.1) months] when compared to male patients [96.5%/86.6%; median survival 63.9 (45.8-82.0) months]. Parameters associated with survival were NT-proBNP, NYHA class, heart rate, midventricular longitudinal strain, mitral annular plane systolic excursion (MAPSE), Karnofsky Index, systolic blood pressure, estimated glomerular filtration rate. Multivariable analysis revealed MAPSE and NT-proBNP as independent predictors of mortality in the whole cohort and midventricular strain in the subgroup of patients in sinus rhythm.

conclusionsNo sex-specific bias was observed between male and female patients with wt-ATTR regarding age at onset and morphological characteristics. Multivariable analysis revealed MAPSE and NT-proBNP as independent predictors of survival in the whole cohort, whereas midventricular longitudinal strain was the only independent predictor in patients in sinus rhythm.

Indexed as

AgedAged, 80 and overAmyloid Neuropathies, FamilialBiomarkersBlood PressureCardiomyopathiesEchocardiographyElectrocardiographyFemaleGermanyHeart RateHumansKaplan-Meier EstimateKarnofsky Performance StatusMaleMitral ValveBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)AmyloidosisSex differencesStrain rate imagingSurvivalTransthyretin

Identifiers

PMID28956153
OpenAlexW2757242206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.