ArticleEuropean radiology2018
The effects of mild germinal matrix-intraventricular haemorrhage on the developmental white matter microstructure of preterm neonates: a DTI study.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Being born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Histopathological and functional Characterization of a neonatal mouse model of intraventricular hemorrhage.Neuroscience · 2025Article
- Early prediction of intraventricular hemorrhage in very low birth weight infants using deep neural networks with attention in low-resource settings.Scientific reports · 2025Article
- Do Different Amounts of Exogenous Surfactant Differently Influence Cerebrovascular Instability in a Consecutive Group of Preterm Babies? Preliminary Results from a Single-Center Experience.Children (Basel, Switzerland) · 2024Article
- Associations between diffusion kurtosis imaging metrics and neurodevelopmental outcomes in neonates with low-grade germinal matrix and intraventricular hemorrhage.Scientific reports · 2024Article
- Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage.Scientific reports · 2024Article
- Ventilatory Support, Extubation, and Cerebral Perfusion Changes in Pre-Term Neonates: A Near Infrared Spectroscopy Study.Neurotrauma reports · 2024Article
- Multi-view fusion of diffusion MRI microstructural models: a preterm birth study.Frontiers in neuroscience · 2024Article
- White matter microstructure predicts individual differences in infant fear (But not anger and sadness).Developmental science · 2023Article
- Deep cerebral venous abnormalities in premature babies with GMH-IVH: a single-centre retrospective study.BMJ paediatrics open · 2023Article
- Racial disparities in the development of comorbid conditions after preterm birth: A narrative review.Seminars in perinatology · 2022Review
- Neuroimaging of structural and functional connectivity in preterm infants with intraventricular hemorrhage.Seminars in perinatology · 2022Review
- Turkish Neonatal Society Guideline on the Diagnosis and Management of Germinal Matrix Hemorrhage-Intraventricular Hemorrhage and Related Complications.Turkish archives of pediatrics · 2022Article
- The Impact of Different Degrees of Intraventricular Hemorrhage on Mortality and Neurological Outcomes in Very Preterm Infants: A Prospective Cohort Study.Frontiers in neurology · 2022Article
- Structural and functional brain connectivity in moderate-late preterm infants with low-grade intraventricular hemorrhage.Neuroradiology · 2022Article
- Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.Neuroradiology · 2021Article
- White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies.Nature reviews. Neurology · 2021Review
- Nosological Differences in the Nature of Punctate White Matter Lesions in Preterm Infants.Frontiers in neurology · 2021Article
- Regional impairment of cortical and deep gray matter perfusion in preterm neonates with low-grade germinal matrix-intraventricular hemorrhage: an ASL study.Neuroradiology · 2020Observational
- Feed-forward neural networks using cerebral MR spectroscopy and DTI might predict neurodevelopmental outcome in preterm neonates.European radiology · 2020Article
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Authors and funding
10 authors.
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Abstract
objectivesTo evaluate white matter (WM) microstructural changes in preterm neonates (PN) with mild germinal matrix-intraventricular haemorrhage (mGMH-IVH) (grades I and II) and no other associated MRI abnormalities, and correlate them with gestational age (GA) and neurodevelopmental outcome.
methodsTract-based spatial-statistics (TBSS) was performed on DTI of 103 patients studied at term-equivalent age, to compare diffusional parameters (fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)) between mGMH-IVH neonates (24/103) and controls matched by GA at birth and sex. The relationship between DTI abnormalities, GA and neurodevelopmental outcome assessed with Griffiths' Developmental Scale-Revised:0-2 was explored using TBSS and Spearman-correlation analysis (p < .05).
resultsAffected neonates had lower FA, higher RD and MD of the corpus callosum, limbic pathways and cerebellar tracts. Extremely preterm neonates (GA < 29 weeks) presented more severe microstructural impairment (higher RD and MD) in periventricular regions. Neonates of GA ≥ 29 weeks had milder WM alterations (lower FA), also in subcortical WM. DTI abnormalities were associated with poorer locomotor, eye-hand coordination and performance outcomes at 24 months.
conclusionsWM microstructural changes occur in PN with mGMH-IVH with a GA-dependent selective vulnerability of WM regions, and correlate with adverse neurodevelopmental outcome at 24 months. KEY POINTS: • DTI-TBSS analysis identifies WM microstructural changes in preterm neonates with mGMH-IVH. • Extremely preterm neonates with mGMH-IVH presented more severe impairment of WM microstructure. • Extremely preterm neonates with mGMH-IVH presented microstructural impairment of periventricular WM. • mGMH-IVH affects subcortical WM in preterm neonates with gestational age ≥ 29 weeks. • WM microstructural alterations are related to neurodevelopmental impairments at 24 months.
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