Evidence map›Paper›PMID 28956099›Full record

ArticleArchives of toxicology2018

Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 β cells.

E N Dover, R Beck, M C Huang, C Douillet, Z Wang, E L Klett, Miroslav Stýblo

Abstract read
In one paragraph

Article in Archives of toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 49 citations in OpenAlex.

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  19. Linoleic acid and the regulation of glucose homeostasis: A review of the evidence.Prostaglandins, leukotrienes, and essential fatty acids · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

E N DoverCurriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
R BeckDepartment of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
M C HuangCurriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
C DouilletDepartment of Nutrition, CB# 74612, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599-7461, USA.
Z WangSchool of Environmental Science and Engineering, Shandong University, No. 27 Shanda South Road, Jinan, 250100, China.
E L KlettDepartment of Nutrition, CB# 74612, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599-7461, USA.
Miroslav StýbloDepartment of Nutrition, CB# 74612, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599-7461, USA. styblo@med.unc.edu.
University of North Carolina at Chapel Hill · USShandong University · CN

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
Lipid Metabolism and Beta-cell FunctionR01DK107481 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KLETT, ERIC · 2016 to 2020
$1.7M
Mechanisms of Arsenic-Induced Diabetes Mellitus - Administrative SupplementR01ES022697 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STYBLO, MIROSLAV · 2014 to 2017
$1.5M
Role of acyl-CoA synthetases in mouse pancreatic ??-cell functionK08DK090141 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KLETT, ERIC · 2010 to 2014
$775k
NIDDK NIH HHS DK056350NIDDK NIH HHS K08 DK090141NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK107481NIEHS NIH HHS R01 ES022697NIEHS NIH HHS T32 ES007126NIH HHS R01DK10748NIH HHS R01ES022697
6 · The paper itself

Abstract

Growing evidence suggests that exposure to environmental contaminants contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a drinking water and food contaminant, is one of the most widespread environmental diabetogens according to epidemiological studies. Several schemes have been proposed to explain the diabetogenic effects of iAs exposure; however, the exact mechanism remains unknown. We have shown that in vitro exposure to low concentrations of arsenite (iAs

Indexed as

AnimalsArsenitesCacodylic AcidCell LineCell SurvivalGlucoseInsulin-Secreting CellsInsulin SecretionMitochondriaOxygenRatsarseniteArsenitesCacodylic Aciddimethylarsinous acidGlucosemethylarsoniteOxygenArsenicDiabetesInsulin secretionMitochondrial respirationβ cells

Identifiers

PMID28956099
PMCPMC6640649
OpenAlexW2757990158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.