Evidence map›Paper›PMID 28956005›Full record

ArticleBiochemistry and biophysics reports2017

Development of a subunit vaccine for prevention of

Alexey Gribenko, Elena Severina, Maninder K Sidhu, Kathrin U Jansen, Bruce A Green, Yury V Matsuka

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alexey GribenkoPfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Elena SeverinaPfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Maninder K SidhuPfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Kathrin U JansenPfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Bruce A GreenPfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Yury V MatsukaPfizer Vaccine Research and Development, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Pfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inactivation of bacterial toxins for use in human vaccines traditionally is achieved by treatment with formaldehyde. In contrast, the bivalent experimental vaccine for the prevention of

Indexed as

ANS, 1-anilinonaphtalene-8-sulfonic acidBiophysical characterizationCD, circular dichroism spectroscopyC. difficileDSC, differential scanning calorimetryEDC, 1-ethyl-3-[3–dimethylaminopropyl]carbodiimide hydrochlorideNHS, N-hydroxysulfosuccinimidePBS, Phosphate buffered salinePM TcdB, D286A/D288A/C698A/E970K/E976K toxin B penta mutantSubunit vaccineTcdA, wild type toxin ATcdB, wild type toxin BTM TcdA, D285A/D287A/C700A toxin A triple mutantTM TcdB, D286A/D288A/C698A toxin B triple mutantToxins/toxoids A and BTxdA, EDC/NHS-treated D285A/D287A/C700A toxoid A triple mutantTxdB, EDC/NHS-treated D286A/D288A/C698A toxoid B triple mutant

Identifiers

PMID28956005
PMCPMC5614615
OpenAlexW2569374898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.