Evidence map›Paper›PMID 28955986›Full record

ArticleBiochemistry and biophysics reports2017

nsPEF-induced PIP

Gleb P Tolstykh, Gary L Thompson, Hope T Beier, Zachary A Steelman, Bennett L Ibey

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Gleb P TolstykhGeneral Dynamics Information Technology, JBSA Fort Sam Houston, TX, USA.
Gary L ThompsonOak Ridge Institute for Science & Education, JBSA Fort Sam Houston, TX, USA.
Hope T BeierAir Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bioeffects Branch, JBSA Fort Sam Houston, TX, USA.
Zachary A SteelmanDuke University, Durham, NC, USA.
Bennett L IbeyAir Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Radio Frequency Bioeffects Branch, JBSA Fort Sam Houston, TX, USA.
59th Medical Wing · US711th Human Performance WingDuke University · USGeneral Dynamics (United States) · USOak Ridge Institute for Science and Education

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell swelling and blebbing has been commonly observed following nanosecond pulsed electric field (nsPEF) exposure. The hypothesized origin of these effects is nanoporation of the plasma membrane (PM) followed by transmembrane diffusion of extracellular fluid and disassembly of cortical actin structures. This investigation will provide evidence that shows passive movement of fluid into the cell through nanopores and increase of intracellular osmotic pressure are not solely responsible for this observed phenomena. We demonstrate that phosphatidylinositol-4,5-bisphosphate (PIP

Indexed as

CalciumCellular swelling and blebbingNanoporesNanosecond pulsed electric fieldPIP2 hydrolysis

Identifiers

PMID28955986
PMCPMC5614542
OpenAlexW2552861607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.