Evidence map›Paper›PMID 28955967›Full record

ArticleBiochemistry and biophysics reports2016

Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM).

Shin Yamamoto, Yusuke Oshima, Takashi Saitou, Takao Watanabe, Teruki Miyake, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shin YamamotoDepartment of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Japan.
Yusuke OshimaDepartment of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Japan.
Takashi SaitouDepartment of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Japan.
Takao WatanabeDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Teruki MiyakeDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Osamu YoshidaDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Yoshio TokumotoDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Masanori AbeDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Bunzo MatsuuraDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Yoichi HiasaDepartment of Gastroenterology and Metabiology, Ehime University Graduate School of Medicine, Japan.
Takeshi ImamuraDepartment of Molecular Medicine for Pathogenesis, Ehime University Graduate School of Medicine, Japan.
Ehime University · JPJapan Science and Technology Agency · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic steatohepatitis (NASH) is a common liver disorder caused by fatty liver. Because NASH is associated with fibrotic and morphological changes in liver tissue, a direct imaging technique is required for accurate staging of liver tissue. For this purpose, in this study we took advantage of two label-free optical imaging techniques, second harmonic generation (SHG) and auto-fluorescence (AF), using two-photon excitation microscopy (TPEM). Three-dimensional

Indexed as

AF, auto-fluorescenceCollagenFibrosisFluorescence imagingNASHNASH, non-alcoholic steatohepatitisSHGSHG, second harmonic generationTPEM, two-photon excitation microscopyTwo-photon excitation microscopy

Identifiers

PMID28955967
PMCPMC5614464
OpenAlexW2522023586

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.