Evidence map›Paper›PMID 28955948›Full record

ArticleBiochemistry and biophysics reports2016

Biochemical and biophysical characterization of

Pragati Agnihotri, Saurabh P Singh, Anil Kumar Shakya, J Venkatesh Pratap

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Pragati AgnihotriMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, B.S. 10/1, sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, UP, India.
Saurabh P SinghDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Anil Kumar ShakyaMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, B.S. 10/1, sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, UP, India.
J Venkatesh PratapMolecular and Structural Biology Division, CSIR-Central Drug Research Institute, B.S. 10/1, sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, UP, India.
Central Drug Research Institute · INWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-glutamylcysteine synthetase (Gcs) is a vital enzyme catalyzing the first and rate limiting step in the trypanothione biosynthesis pathway, the ATP-dependent ligation of L-Glutamate and L-Cysteine to form gamma-glutamylcysteine. The Trypanothione biosynthesis pathway is unique metabolic pathway essential for trypanosomatid survival rendering Gcs as a potential drug target. Here we report the cloning, expression, purification and characterization of

Indexed as

Divalent ionGlutamyl cysteine synthetaseL donovaniPolyamine biosynthesis pathwaySubstrate binding

Identifiers

PMID28955948
PMCPMC5613772
OpenAlexW2510087393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.