ArticleBiochemistry and biophysics reports2016
Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated
Article in Biochemistry and biophysics reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Role of Carbohydrate response element-binding protein in mediating dexamethasone-induced glucose transporter 5 expression in Caco-2BBE cells and during the developmental phase in mice.Animal cells and systems · 2024Article
- Regulation of Carbohydrate-Responsive Metabolic Genes by Histone Acetylation and the Acetylated Histone Reader BRD4 in the Gene Body Region.Frontiers in molecular biosciences · 2021Review
- BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene.Scientific reports · 2017Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExpression of the fructose transporter gene
methodsWe co-treated with glucocorticoid receptor agonist dexamethasone (Dex) and p44/42 MAPK inhibitor PD98059 (PD) in Caco-2 cells with or without Brd4 small hairpin (sh) RNA expression vector, and the cells were analyzed by qRT-PCR and chromatin immunoprecipitation assays. The small intestine of wild-type mice and
resultsCo-treatment with Dex and PD increased binding of the bromodomain-containing protein-4 (Brd4)-positive transcriptional elongation factor-b (P-TEFb)-RNA polymerase II complex to acetylated histones in the transcribed region of
conclusionsBrd4-P-TEFb plays a crucial role in differentiation-associated transcription of GENERAL SIGNIFICANCE: Histone acetylation and the transcription elongation factor Brd4 are important for
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Registered trials
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