Evidence map›Paper›PMID 28955781›Full record

ArticleBiochemistry and biophysics reports2017

An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways.

Dayane Sereno, Werner E G Müller, Melanie Bausen, Tarek A Elkhooly, Julia S Markl, Matthias Wiens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. UPR Responsive GenesFrontiers in cellular neuroscience · 2022
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dayane SerenoInstitute for Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany.
Werner E G MüllerInstitute for Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany.
Melanie BausenInstitute for Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany.
Tarek A ElkhoolyInstitute for Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany.
Julia S MarklInstitute for Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany.
Matthias WiensInstitute for Physiological Chemistry, University Medical Center, Johannes Gutenberg-University, Duesbergweg 6, D-55128 Mainz, Germany.
Johannes Gutenberg University Mainz · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mesencephalic astrocyte-derived neurotrophic factor (MANF) belongs to a recently discovered family of neurotrophic factors. MANF can be secreted but is generally resident within the endoplasmic reticulum (ER) in neuronal and non-neuronal cells, where it is involved in the ER stress response with pro-survival effects. Here we report the discovery of the MANF homolog SDMANF in the sponge

Indexed as

ApoptosisER stressEvolutionInnate immunityMANFPorifera

Identifiers

PMID28955781
PMCPMC5614693
OpenAlexW2595615471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.