Evidence map›Paper›PMID 28955743›Full record

ArticleBiochemistry and biophysics reports2017

The effect of alcohol on recombinant proteins derived from mammalian adenylyl cyclase.

Emily Qualls-Creekmore, Ratna Gupta, Masami Yoshimura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily Qualls-CreekmoreDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, United States.
Ratna GuptaDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, United States.
Masami YoshimuraDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, United States.
Louisiana State University · US

Funding

Action of Ethanol on Cyclic AMP Signal TransductionR01AA013148 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI YOSHIMURA, MASAMI · 2002 to 2013
$2.5M
Action of Ethanol on Cyclic AMP Signal TransductionR56AA013148 · NIAAA · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI YOSHIMURA, MASAMI · 2008 to 2008
$344k
NIAAA NIH HHS R01 AA013148NIAAA NIH HHS R56 AA013148
6 · The paper itself

Abstract

The cyclic AMP (cAMP) signaling pathway is implicated in the development of alcohol use disorder. Previous studies have demonstrated that ethanol enhances the activity of adenylyl cyclase (AC) in an isoform specific manner; AC7 is most enhanced by ethanol, and regions responsible for enhancement by ethanol are located in the cytoplasmic domains of the AC7 protein. We hypothesize that ethanol modulates AC activity by directly interacting with the protein and that ethanol effects on AC can be studied using recombinant AC

Indexed as

AC, Adenylyl cyclaseAdenylyl cyclaseAlcoholcAMP, Cyclic AMPDKO, Double knock outEthanolForskolinGppNHp, Guanosine 5′-[β,γ-imido]triphosphateGsαKO, Knock outPMSF, phenylmethylsulfonyl fluorideRecombinant proteinSDS-PAGE, Sodium dodecyl sulfate-polyacrylamide gel electrophoresis

Identifiers

PMID28955743
PMCPMC5614657
OpenAlexW2602337243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.