Bisphenol A inhibits compound action potentials in the frog sciatic nerve in a manner independent of estrogen receptors.

Kotaro Mizuta, Tsugumi Fujita, Hiroki Yamagata, Eiichi Kumamoto

Abstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Bisphenol A and its effects on the systemic organs of children.European journal of pediatrics · 2021
Review
Inhibition of Fast Nerve Conduction Produced by Analgesics and Analgesic Adjuvants-Possible Involvement in Pain Alleviation.Pharmaceuticals (Basel, Switzerland) · 2020
Review
Inhibition by general anesthetic propofol of compound action potentials in the frog sciatic nerve and its chemical structure.Naunyn-Schmiedeberg's archives of pharmacology · 2019
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kotaro MizutaDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.

Tsugumi FujitaDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.

Hiroki YamagataDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.

Eiichi KumamotoDepartment of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the endocrine disruptor bisphenol A (BPA) is reported to inhibit nerve conduction, the underlying mechanisms are unclear. Therefore, in the present study, we examined the effect of BPA on compound action potentials (CAPs) recorded from the frog sciatic nerve using the air-gap method. Treatment of the sciatic nerve with BPA (0.5 mM) for 20 min reduced the peak amplitude of the CAP by approximately 60% in a partially reversible manner. The reduction in the CAP peak amplitude was concentration-dependent, with a half-maximal inhibitory concentration (IC

Indexed as

17β-Estradiol4-OHT, 4-hydroxytamoxifenBisphenol ABPA, bisphenol ACAP, compound action potentialDMSO, dimethyl sulfoxideDRG, dorsal root ganglionERRγ, estrogen-related receptor γERα, estrogen receptor αERβ, estrogen receptor βFrogIC50, half-maximal inhibitory concentrationLA, local anestheticLocal anestheticNerve conduction inhibitionnH, Hill coefficientSciatic nerveTTX, tetrodotoxin

Identifiers

PMID28955742

DOI10.1016/j.bbrep.2017.03.006

PMCPMC5614631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.