ArticleeNeuro
Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- How early olfactory experiences influence brain development in mice.Frontiers in neural circuits · 2025Review
- Olfactory Critical Periods: How Odor Exposure Shapes the Developing Brain in Mice and Flies.Biology · 2024Review
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Article
- Nasal anatomy and sniffing in respiration and olfaction of wild and domestic animals.Frontiers in veterinary science · 2023Review
- The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.eLife · 2021Article
- Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation during an Early-Life Critical Period.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Developmental regulation of olfactory circuit formation in mice.Development, growth & differentiation · 2020Review
- Decreased amplitude and reliability of odor-evoked responses in two mouse models of autism.Journal of neurophysiology · 2020Article
- Complex neural representation of odour information in the olfactory bulb.Acta physiologica (Oxford, England) · 2020Review
- The effect of odor enrichment on olfactory acuity: Olfactometric testing in mice using two mirror-molecular pairs.PloS one · 2020Article
- Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction.Journal of bioenergetics and biomembranes · 2019Review
- Strength in diversity: functional diversity among olfactory neurons of the same type.Journal of bioenergetics and biomembranes · 2019Review
- The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- What can a worm learn in a bacteria-rich habitat?Journal of neurogeneticsReview
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Early sensory experience shapes the anatomy and function of sensory circuits. In the mouse olfactory bulb (OB), prenatal and early postnatal odorant exposure through odorized food (food/odorant pairing) not only increases the volume of activated glomeruli but also increases the number of mitral and tufted cells (M/TCs) connected to activated glomeruli. Given the importance of M/TCs in OB output and in mediating lateral inhibitory networks, increasing the number of M/TCs connected to a single glomerulus may significantly change odorant representation by increasing the total output of that glomerulus and/or by increasing the strength of lateral inhibition mediated by cells connected to the affected glomerulus. Here, we seek to understand the functional impact of this long-term odorant exposure paradigm on the population activity of mitral cells (MCs). We use viral expression of GCaMP6s to examine odor-evoked responses of MCs following prenatal and early postnatal odorant exposure to two dissimilar odorants, methyl salicylate (MS) and hexanal, which are both strong activators of glomeruli on the dorsal OB surface. Previous work suggests that odor familiarity may decrease odor-evoked MC response in rodents. However, we find that early food-based odorant exposure significantly changes MC responses in an unexpected way, resulting in broad increases in the amplitude, number, and reliability of excitatory MC responses across the dorsal OB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.