ArticleIranian journal of otorhinolaryngology2017
Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region.
Article in Iranian journal of otorhinolaryngology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Determinants of pesticide safety behaviors among Iranian farmers: applying the health action model.BMC public health · 2025Article
- Occupations and Risk of Head and Neck Cancers: A Case-Control Study in Tanzania.International journal of environmental research and public health · 2025Article
- Occupational Risk Factors for Laryngeal Cancer in Tunisia: A Case Control Study.La Medicina del lavoro · 2023Article
- Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study.International journal of environmental research and public health · 2023Observational
- Demography and Pattern of Tobacco Usage in Carcinoma of Upper Aerodigestive Tract.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity.Oxidative medicine and cellular longevity · 2022Review
- Head and neck cancer risk factors in the French West Indies.BMC cancer · 2021Article
- Occupational Exposure to Carcinogens and Occupational Epidemiological Cancer Studies in Iran: A Review.Cancers · 2021Review
- Amitraz induced cytotoxic effect on bovine cumulus cells and impaired oocyte maturation.Environmental science and pollution research international · 2021Article
- The pesticides use and the risk for head and neck cancer: A review of case-control studies.Medicina oral, patologia oral y cirugia bucal · 2021Review
- Micronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020Article
- Article
- Clinical Features, Treatment, Prognosis, and Mortality in Paraquat Poisonings: A Hospital-Based Study in Iran.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCauses of head and neck cancers (HNCs) are multifactorial, and few studies have investigated the association between chemical exposure and HNCs. The objective of this study was to investigate associations between HNCs, agricultural occupations, and pesticide exposure. The potential for the accumulation of pesticides in the adipose tissue of patients was also investigated. MATERIALS AND
methodsA structured questionnaire was used to collect information on demographics, occupation, and exposure to pesticides in a hospital-based case-control study. Pesticide residue in the adipose tissue of the neck in both cases and controls was also monitored via gas chromatography-mass spectroscopy.
resultsThirty-one HNC cases were included in this study as well as 32 gender-, age-, and smoking-matched controls. An agricultural occupation was associated with HNC (odds ratio [OR], 3.26; 95% confidence interval [CI], 1.13-9.43) after controlling for age, sex, and smoking. Pesticide exposure was associated with total HNC cases (OR, 7.45; 95% CI, 1.78-3.07) and larynx cancer (OR, 9.33; 95% CI, 1.65-52.68). A dose-response pattern was observed for HNC cases (P=0.06) and larynx cancer (P=0.01). In tracing the pesticide residue, five chlorinated pesticides, namely dichlorodiphenyltrichloroethane (DDT), dichlorodipheny-ldichloroethane (DDD), dichlorodiphenyldichloroethylene (DDE), dieldrin, and lindane, were identified in the adipose tissue. Chlorinated pesticide detection was significantly associated with HNC (OR, 3.91; 95% CI 0.9-0.16.9).
conclusionHNCs were found to be associated with pesticide exposure after controlling for confounders. A high education level was identified as a modifying factor decreasing the risk of HNCs. Further studies with larger number of subjects are recommended to assess these relationships in greater detail.
Indexed as
Identifiers
28955675PMC5610376W2751609248What OpenQuestion holds
Registered trials
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