Evidence map›Paper›PMID 28955504›Full record

ArticleNPJ Regenerative medicine2016

A novel role for SALL4 during scar-free wound healing in axolotl.

Jami R Erickson, Micah D Gearhart, Drew D Honson, Taylor A Reid, Melissa K Gardner, Branden S Moriarity, Karen Echeverri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Regulation of macrophage transcriptional dynamics during acute and chronic wound repair.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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  14. Wound healing across the animal kingdom: Crosstalk between the immune system and the extracellular matrix.Developmental dynamics : an official publication of the American Association of Anatomists · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jami R EricksonDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
Micah D GearhartDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
Drew D HonsonDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
Taylor A ReidDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
Melissa K GardnerDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
Branden S MoriarityDepartment of Pediatrics, University of Minnesota, Center for Genome Engineering, University of Minnesota, Masonic Cancer Center, University of Minnesota, Minnesota, MN USA.
Karen EcheverriDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minnesota, MN, USA.
University of Minnesota · US

Funding

Quantitative Analysis and Modeling of Microtubule Structure and RegulationR01GM103833 · NIGMS · UNIVERSITY OF MINNESOTA · PI GARDNER, MELISSA · 2013 to 2017
$1.4M
Stem Cell Biology Training ProgramT32HD060536 · NICHD · UNIVERSITY OF MINNESOTA · PI KAUFMAN, DAN S. · 2010 to 2014
$779k
NICHD NIH HHS T32 HD060536NIGMS NIH HHS R01 GM103833
6 · The paper itself

Abstract

The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regenerate full thickness wounds. Here, we identified a novel role for SALL4 in regulating collagen transcription after injury that is essential for perfect skin regeneration in axolotl. Furthermore, we identify miR-219 as a molecular regulator of

Identifiers

PMID28955504
PMCPMC5612448
OpenAlexW2560330584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.