Evidence map›Paper›PMID 28955431›Full record

ArticleMalawi medical journal : the journal of Medical Association of Malawi2017

Challenges of stroke management in resource-limited settings: A case-based reflection.

Yohane G Gadama, Gloria Mwangalika, Louis B Kinley, Beth Jackson, Henry C Mwandumba, Jane Mallewa, Tom Solomon, Rob Simister, Laura A Benjamin, Maria I Vargas and 2 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Malawi medical journal : the journal of Medical Association of Malawi, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Targeting Neurovascular Pathways: Gene Therapy as a Novel Treatment for Vascular Dementia After Stroke.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Yohane G GadamaDepartment of Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Gloria MwangalikaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
Louis B KinleyDepartment of Radiology, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Beth JacksonDepartment of Medicine, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Henry C MwandumbaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
Jane MallewaDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
Tom SolomonLiverpool Brain Infections Group, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Rob SimisterHyper-acute Stroke Unit, University College Hospital, London, United Kingdom.
Laura A BenjaminLiverpool Brain Infections Group, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
Maria I VargasDepartment of Neuroradiology, Geneva University Hospital, Geneva, Switzerland.
Joseph Kamtchum-TatueneMalawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
Tamara PhiriDepartment of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.
University of Liverpool · GBQueen Elizabeth Central Hospital · MWUniversity of Malawi · MWLiverpool School of Tropical Medicine · GBUniversity College London · GBUniversity Hospital of Geneva · CH

Funding

Department of Health EME/12/205/28Department of Health IS-HPU-1112-10117Department of Health RP-PG-0108-10048Medical Research Council G116/194Medical Research Council MC_PC_15096
6 · The paper itself

Abstract

A 19-year-old man presented with a 1-year history of headache, generalised body weakness, progressive memory loss, and disorientation. One month prior to admission, there was aggravation of the weakness of the right upper limb, with new-onset difficulty with mastication, speech impairment, apathy, and urinary incontinence. On clinical examination, the patient had a motor aphasia and a right-sided hemiparesis with increased muscle tone and hyperreflexia. A noncontrast computed tomography (CT) scan of the brain revealed large ischaemic strokes extending beyond the classical vascular territories. Cerebrospinal fluid analysis showed a mildly increased protein level. The electrocardiogram revealed an irregular sinus bradycardia. The remainder of the cardiovascular and laboratory workup was unremarkable. Considering a working diagnosis of central nervous system vasculitis, the patient was treated with aspirin, prednisolone, and physiotherapy. However, he died suddenly a few weeks later. Based on this case, we discuss the challenges of stroke management in resource-limited settings, provide practical tips for general practitioners, reflect on the potential avenues for short- and long-term action, and introduce the budding collaboration platform between the University College London, the University of Liverpool, the Queen Elizabeth Central Hospital, and the Malawi-Liverpool-Wellcome Trust Clinical Research Programme.

Indexed as

HeadacheHumansMaleMuscle WeaknessStrokeYoung Adult

Identifiers

PMID28955431
PMCPMC5610294
OpenAlexW2746003350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.