ArticleFrontiers in neurology2017
Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Diagnostic accuracy of the Arabic composite autonomic symptom score 31 (COMPASS-31) for detecting autonomic neuropathy in SLE: a cross-sectional validation study.Lupus science & medicine · 2026Article
- Functional Connectivity Alterations of the Central Autonomic Network in Multiple Sclerosis: Links to Fatigue and Aerobic Training Effects.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Subjective estimation of cognitive function in mild cognitive impairment: relationship with neurodegenerative and non-degenerative factors.Psychological medicine · 2026Article
- Reliability and validity of the Turkish version of the Composite Autonomic Symptom Score in patients with fibromyalgia.Turkish journal of physical medicine and rehabilitation · 2025Article
- Autonomic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Findings from the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study in the USA.Journal of clinical medicine · 2025Article
- Observational
- Autonomic nervous system disorders in multiple sclerosis.Journal of neurology · 2023Review
- Heart rate variability and fatigue in MS: two parallel pathways representing disseminated inflammatory processes?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- Article
- Brain Structural and Functional Alterations in Multiple Sclerosis-Related Fatigue: A Systematic Review.Neurology international · 2022Review
- The therapeutic potential of non-invasive brain stimulation for the treatment of Long-COVID-related cognitive fatigue.Frontiers in immunology · 2022Review
- Unveiling the relationship between autonomic involvement, fatigue, and cognitive dysfunction in early relapsing-remitting multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review).Experimental and therapeutic medicine · 2020Review
- Cardiovascular Autonomic Dysfunction and Falls in People With Multiple Sclerosis: Is There a Link? An Opinion Article.Frontiers in neuroscience · 2020Article
- Herpes Simplex Virus 1 Induces Brain Inflammation and Multifocal Demyelination in the Cotton Rat Sigmodon hispidus.Journal of virology · 2019Article
- Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Investigation of ischemic and demyelinating lesions by cerebral vasoreactivity based on transcranial Doppler sonography: a comparative study.Neuropsychiatric disease and treatment · 2018Article
- Salivary IL-1ß as an Objective Measure for Fatigue in Multiple Sclerosis?Frontiers in neurology · 2018Article
- Cannabidiol to Improve Mobility in People with Multiple Sclerosis.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive fatigue and autonomic abnormalities are frequent symptoms in MS. Our model of MS-related fatigue assumes a shared neural network for cognitive fatigue and autonomic failures, i.e., aberrant vagus nerve activity induced by inflammatory processes. Therefore, they should occur in common.
objectiveTo explore the relationship between cognitive fatigue and autonomic symptoms in MS patients, using self-reported questionnaires.
methodsIn 95 MS patients, cognitive fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions and autonomic abnormalities with the Composite Autonomic Symptom Scale-31 (COMPASS-31). We used exploratory correlational analyses and hierarchical regression analysis, controlling for age, depressive mood, disease status, and disease duration, to analyze the relation between autonomic abnormalities and cognitive fatigue.
resultsThe cognitive fatigue score strongly correlated with the COMPASS-31 score (
conclusionIn MS patients, cognitive fatigue and autonomic dysfunction share a proportion of variance. This supports our model assuming that fatigue might be explained at least partially by inflammation-induced vagus nerve activity.
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