ArticleFrontiers in pharmacology2017
Alginate Oligosaccharide DP5 Exhibits Antitumor Effects in Osteosarcoma Patients following Surgery.
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 118 citations in OpenAlex.
- Alginate oligosaccharides promote wound healing and induce macrophage M2 polarisation by activating the PI3K/AKT1 signalling pathway.Molecular and cellular biochemistry · 2026Article
- [Preparation of a novel polyhydroxy silica stationary phase and application in the separation of alginate oligosaccharides].Se pu = Chinese journal of chromatography · 2026Article
- Enhanced Thermostability and Catalytic Efficiency of Alginate Lyase Alyw203 by Hydrogen Bond Network Reconstruction.Marine drugs · 2025Article
- Heterologous Expression and Functional Characterization of a Truncated Marine Alginate Lyase.Applied biochemistry and biotechnology · 2025Article
- Review
- Recent Advances in Alginate Lyase Engineering for Efficient Conversion of Alginate to Value-Added Products.Microbial biotechnology · 2025Review
- Multi-Functional Alginate LyaseMarine drugs · 2025Article
- Advances in alginate biosynthesis: regulation and production inFrontiers in bioengineering and biotechnology · 2025Review
- Exploring New Frontiers: Alternative Breast Cancer Treatments Through Glycocalyx Research.The breast journal · 2025Review
- Genome Analysis of a Potential NovelMarine drugs · 2024Article
- Enhanced algin oligosaccharide production through selective breeding and optimization of growth and degradation conditions in Cobetia sp. cqz5-12-M1.Scientific reports · 2024Article
- Alginate oligosaccharide assimilation by gut microorganisms and the potential role in gut inflammation alleviation.Applied and environmental microbiology · 2024Article
- Bioarchitectural Design of Bioactive Biopolymers: Structure-Function Paradigm for Diabetic Wound Healing.Biomimetics (Basel, Switzerland) · 2024Review
- Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis.Theranostics · 2024Article
- Advances in oligosaccharides production from brown seaweeds: extraction, characterization, antimetabolic syndrome, and other potential applications.Bioengineered · 2023Review
- Cost-effective production of alginate oligosaccharides from Laminaria japonica roots by Pseudoalteromonas agarivorans A3.Microbial cell factories · 2023Article
- A Novel Cold-Adapted and High-Alkaline Alginate Lyase with Potential for Alginate Oligosaccharides Preparation.Molecules (Basel, Switzerland) · 2023Article
- Structural and Physical Properties of Alginate Pretreated by High-Pressure Homogenization.Polymers · 2023Article
- Antioxidant Activities, Anticancer Activity, Physico-Chemistry Characteristics, and Acute Toxicity of Alginate/Lignin Polymer.Molecules (Basel, Switzerland) · 2023Article
- Recent advances in the production, properties and applications of alginate oligosaccharides - a mini review.World journal of microbiology & biotechnology · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma is a malignant musculoskeletal tumor that has high-rate morbidity and mortality worldwide. Alginate oligosaccharide (AOS), a natural product, has antitumor activities and may have therapeutic effects in osteosarcoma, the molecular mechanisms of which remain unclear. AOS was prepared from alginate sodium using alginate lyase. The fractions of AOS were further isolated by size-exclusion chromatography and verified by electrospray ionization mass spectrometry (ESI-MS). Osteosarcoma patients were enrolled in the study and assigned into two groups: AOS (AG, oral administration of 10-mg AOS daily) and control groups (CG, placebo). Preoperative and postoperative clinical data were investigated and analyzed. Four different degrees of polymerizations (DPs) were isolated and denominated as DP2, DP3, DP4, and DP5. Among these polymers, only DP5 showed antitumor functions on osteosarcoma cells. Before surgery and the outcome of primary end point after surgery, no significant differences were observed for clinical data and tumor size between the AG and CG groups (
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