ArticleScientific reports2017
The mechanism (Phe362Tyr mutation) behind resistance in Lepeophtheirus salmonis pre-dates organophosphate use in salmon farming.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Delousing performance of ballan wrasse (Labrus bergylta) and lumpfish (Cyclopterus lumpus): seasonal consistency and the challenge of cryptic lice for lumpfish.Pest management science · 2026Article
- Modelling the Effectiveness of Gene-Edited Salmon at Sea Lice Control and the Use of Refugia to Mitigate Counter-Adaptation.Evolutionary applications · 2025Article
- Evolutionary predictions for a parasite metapopulation: Modelling salmon louse resistance to pest controls in aquaculture.Evolutionary applications · 2023Article
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- A modeling study of the impact of treatment policies on the evolution of resistance in sea lice on salmon farms.PloS one · 2023Article
- The salmon louse genome may be much larger than sequencing suggests.Scientific reports · 2022Article
- Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway.International journal of molecular sciences · 2022Review
- IIb-RAD-sequencing coupled with random forest classification indicates regional population structuring and sex-specific differentiation in salmon lice (Ecology and evolution · 2022Article
- The potential for cleaner fish-driven evolution in the salmon louseEcology and evolution · 2021Article
- Not that clean: Aquaculture-mediated translocation of cleaner fish has led to hybridization on the northern edge of the species' range.Evolutionary applications · 2021Article
- Losing the 'arms race': multiresistant salmon lice are dispersed throughout the North Atlantic Ocean.Royal Society open science · 2021Article
- Article
- "A cleaner break": Genetic divergence between geographic groups and sympatric phenotypes revealed in ballan wrasse (Ecology and evolution · 2020Article
- Article
- The Phe362Tyr mutation conveying resistance to organophosphates occurs in high frequencies in salmon lice collected from wild salmon and trout.Scientific reports · 2017Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The salmon louse is an ectoparasitic copepod of salmonids in the marine environment, and represents a global challenge to salmon aquaculture. A major issue is the reliance of the industry on a limited number of chemicals to delouse salmonids on farms, and the high levels of resistance that lice have developed to all of these agents. However, for most of these chemicals, resistance and dispersal mechanisms are unknown. We recently demonstrated that the Phe362Tyr mutation is the primary cause of organophosphate resistance in lice collected on Norwegian farms. In the present study, we genotyped >2000 lice collected throughout the entire North Atlantic in the period 1998-2016, using Phe362Tyr and nine tightly linked SNPs. Our results showed that the Phe362Tyr mutation is strongly linked to lice survival following chemical treatment on farms located throughout the North Atlantic, demonstrating for the first time, that this mutation represents the primary mechanism for organophosphate resistance in salmon lice across the North Atlantic. Additionally, we observed multiple and diverse high frequency haplotypes linked with the allele conveying resistance to organophosphate. We, therefore, conclude that Phe362Tyr is not a de novo mutation, but probably existed in salmon lice before the introduction of organophosphates in commercial aquaculture.
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