ArticleScientific reports2017
Effect of Transforming Growth Factor-β upon Taenia solium and Taenia crassiceps Cysticerci.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Parasites as Modulators of Angiogenesis: Implications for Vascular Biology and Pathogenesis.Pathogens (Basel, Switzerland) · 2026Review
- Transcriptomic analysis of subarachnoid cysts of Taenia solium reveals mechanisms for uncontrolled proliferation and adaptations to the microenvironment.Scientific reports · 2024Article
- Current Role of Surgery in the Treatment of Neurocysticercosis.Pathogens (Basel, Switzerland) · 2024Review
- Transforming growth factor-β signalling regulates protoscolex formation in theFrontiers in cellular and infection microbiology · 2023Article
- Identification and expression of a transforming growth factor beta (TGF-β) homologue in the tropical liver fluke Fasciola gigantica.Parasitology research · 2022Article
- Article
- Importance of TGFβ in Cancer and Nematode Infection and Their Interaction-Opinion.Biomolecules · 2022Review
- Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions.Antioxidants (Basel, Switzerland) · 2022Review
- Proliferative cells in racemose neurocysticercosis have an active MAPK signalling pathway and respond to metformin treatment.International journal for parasitology · 2022Article
- Natural history ofFrontiers in veterinary science · 2022Article
- Cellular and molecular basis associated with metacestode proliferation in subarachnoid neurocysticercosis.Frontiers in immunology · 2022Article
- The Local Inflammatory Profile and Predictors of Treatment Success in Subarachnoid Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.PLoS neglected tropical diseases · 2021Article
- A novel, sequencing-free strategy for the functional characterization of Taenia solium proteomic fingerprint.PLoS neglected tropical diseases · 2021Article
- Swine cysticercosis and associated risk factors in non-technified pig breeding in semi-arid region of Sergipe state, Brazil.Tropical animal health and production · 2020Article
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction.PLoS neglected tropical diseases · 2019Article
- Human Extraparenchymal Neurocysticercosis: The Control of Inflammation Favors the Host…but Also the Parasite.Frontiers in immunology · 2018Article
- The Effect of Alpha-Tocopherol on the Expression of Epidermal Growth Factor Receptor and Transforming Growth Factor Beta Genes in Three Developmental Stages ofIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taeniids exhibit a great adaptive plasticity, which facilitates their establishment, growth, and reproduction in a hostile inflammatory microenvironment. Transforming Growth Factor-β (TGFβ), a highly pleiotropic cytokine, plays a critical role in vertebrate morphogenesis, cell differentiation, reproduction, and immune suppression. TGFβ is secreted by host cells in sites lodging parasites. The role of TGFβ in the outcome of T. solium and T. crassiceps cysticercosis is herein explored. Homologues of the TGFβ family receptors (TsRI and TsRII) and several members of the TGFβ downstream signal transduction pathway were found in T. solium genome, and the expression of Type-I and -II TGFβ receptors was confirmed by RT-PCR. Antibodies against TGFβ family receptors recognized cysticercal proteins of the expected molecular weight as determined by Western blot, and different structures in the parasite external tegument. In vitro, TGFβ promoted the growth and reproduction of T. crassiceps cysticerci and the survival of T. solium cysticerci. High TGFβ levels were found in cerebrospinal fluid from untreated neurocysticercotic patients who eventually failed to respond to the treatment (P = 0.03) pointing to the involvement of TGFβ in parasite survival. These results indicate the relevance of TGFβ in the infection outcome by promoting cysticercus growth and treatment resistance.
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