Evidence map›Paper›PMID 28954890›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype.

Lillian Seu, Christopher Tidwell, Laura Timares, Alexandra Duverger, Frederic H Wagner, Paul A Goepfert, Andrew O Westfall, Steffanie Sabbaj, Olaf Kutsch

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. CD151 interacts with integrin beta 2 in B cell lymphomas.Cellular and molecular life sciences : CMLS · 2025
    Article
  4. Review
  5. Article
  6. Genetic susceptibility loci forFrontiers in immunology · 2022
    Article
  7. Tetraspanins: Host Factors in Viral Infections.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lillian SeuDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 lillian.seu@gmail.com okutsch@uab.edu.ORCID 0000-0002-8456-019X
Christopher TidwellDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0002-9739-2244
Laura TimaresDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0001-8886-8354
Alexandra DuvergerDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
Frederic H WagnerDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
Paul A GoepfertDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0001-8441-5737
Andrew O WestfallDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0002-0468-4695
Steffanie SabbajDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0003-4052-6819
Olaf KutschDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 lillian.seu@gmail.com okutsch@uab.edu.ORCID 0000-0002-1853-8023
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Overcoming HIV-1 transcriptional latency in unresponsive CD4 T cellsR01AI122842 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2017 to 2020
$2.6M
HTS for Synergistic Activators of Latent HIV-1 InfectionR01AI104499 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2013 to 2015
$1.6M
Kinomic analysis of host cell factors controlling latent HIV-1 infectionR33AI116188 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2016 to 2018
$1.3M
Kinomic analysis of host cell factors controlling latent HIV-1 infectionR21AI116188 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2014 to 2015
$551k
Overcoming HIV-1 transcriptional latency in unresponsive CD4 T cellsR56AI122842 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2016 to 2016
$455k
Oxidative stress and T cell balance: Effect on pulmonary tuberculosis during HIVF32HL121924 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SEU, LILLIAN · 2014 to 2015
$116k
NCI NIH HHS P30 CA013148NHLBI NIH HHS F32 HL121924NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI104499NIAID NIH HHS R01 AI122842NIAID NIH HHS R21 AI116188NIAID NIH HHS R33 AI116188NIAID NIH HHS R56 AI122842NIAMS NIH HHS P30 AR048311
6 · The paper itself

Abstract

The tetraspanin CD151 is a marker of aggressive cell proliferation and invasiveness for a variety of cancer types. Given reports of CD151 expression on T cells, we explored whether CD151 would mark T cells in a hyperactivated state. Consistent with the idea that CD151 could mark a phenotypically distinct T cell subset, it was not uniformly expressed on T cells. CD151 expression frequency was a function of the T cell lineage (CD8 > CD4) and a function of the memory differentiation state (naive T cells < central memory T cells < effector memory T cells < T effector memory RA

Indexed as

Cell ProliferationCD28 AntigensCD4-Positive T-LymphocytesCD57 AntigensCD8-Positive T-LymphocytesCellular SenescenceGene Expression RegulationHumansTetraspanin 24CD151 protein, humanCD28 AntigensCD57 AntigensTetraspanin 24

Identifiers

PMID28954890
PMCPMC5654656
OpenAlexW2758342427

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.