Observational studyPediatrics2017
Chronic Auditory Toxicity in Late Preterm and Term Infants With Significant Hyperbilirubinemia.
Observational study in Pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Biological markers of hearing loss in neonates admitted to the neonatal intensive care unit: a systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- [Guidelines for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal jaundice (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Guideline
- Is auditory neuropathy an appropriate term? A systematic literature review on its aetiology and pathogenesis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Pooled it
- Stannsoporfin with phototherapy to treat hyperbilirubinemia in newborn hemolytic disease.Journal of perinatology : official journal of the California Perinatal Association · 2022Trial
- Cochlear implantation for sensorineural hearing loss caused by neonatal hyperbilirubinemia.Seminars in perinatology · 2026Review
- Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study.Heliyon · 2024Article
- Hyperbilirubinemia Requiring Exchange Transfusion as a Risk Factor for Later-Onset Hearing Loss.Journal of early hearing detection and intervention · 2024Article
- Article
- Effects of bilirubin on the development and electrical activity of neural circuits.Frontiers in cellular neuroscience · 2023Review
- High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates.Italian journal of pediatrics · 2021Article
- Preterm Neonatal Mortality and its predictors in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a retrospective cohort study.Ethiopian journal of health sciences · 2021Article
- Effect of Hyperbilirubinemia on Medial Olivocochlear System in Newborns.The journal of international advanced otology · 2020Article
- Effect of Hyperbilirubinemia on Medial Olivocochlear System in Newborns.The journal of international advanced otology · 2019Article
- Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders.Pediatric research · 2019Review
- High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.Pediatric research · 2019Review
- Prolonged furosemide exposure and risk of abnormal newborn hearing screen in premature infants.Early human development · 2018Article
- Bilirubin binding in jaundiced newborns: from bench to bedside?Pediatric research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectivesSignificant hyperbilirubinemia (SHB) may cause chronic auditory toxicity (auditory neuropathy spectrum disorder and/or sensorineural hearing loss); however, total serum bilirubin (TSB) does not discriminate neonates at risk for auditory toxicity. Our objective was to compare TSB, bilirubin albumin molar ratio (BAMR), and unbound bilirubin (UB) for their association with chronic auditory toxicity in neonates with SHB (TSB ≥20 mg/dL or TSB that met criteria for exchange transfusion).
methodsInfants ≥34 weeks' gestational age (GA) with SHB during the first 2 postnatal weeks were eligible for a prospective longitudinal study in India. Comprehensive auditory evaluations were performed at 2 to 3 months of age by using auditory brainstem response, tympanometry, and an otoacoustic emission test and at 9 to 12 months of age by using audiometry. The evaluations were performed by an audiologist unaware of the degree of jaundice.
resultsA total of 93 out of 100 infants (mean GA of 37.4 weeks; 55 boys, 38 girls) who were enrolled with SHB were evaluated for auditory toxicity. Of those, 12 infants (13%) had auditory toxicity. On regression analysis controlling for covariates, peak UB (but not peak TSB or peak BAMR), was associated with auditory toxicity (odds ratio 2.41; 95% confidence interval: 1.43-4.07;
conclusionsUnconjugated hyperbilirubinemia indexed by UB (but not TSB or BAMR) is associated with chronic auditory toxicity in infants ≥34 weeks' GA with SHB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.