Evidence map›Paper›PMID 28954762›Full record

ArticleGenetics2017

Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in

Ryan S Underwood, Yuting Deng, Iva Greenwald

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. DistinctmicroPublication biology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Positive autoregulation ofDevelopment (Cambridge, England) · 2020
    Article
  14. Article
  15. Article
  16. Review
  17. Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ryan S UnderwoodDepartment of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032.
Yuting DengDepartment of Biological Sciences, Columbia University, New York, New York 10027.
Iva GreenwaldDepartment of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032 isg4@columbia.edu.
Columbia University Irving Medical Center · USColumbia University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
New modes and mechanisms of negative regulation of LIN-12/Notch in C. elegansR01GM114140 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENWALD, IVA S · 2015 to 2018
$1.4M
Elucidation of Novel Post-Translational Mechanisms That Regulate Notch ActivityF31CA177168 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI UNDERWOOD, RYAN SCOTT · 2013 to 2016
$169k
NCI NIH HHS F31 CA177168NIGMS NIH HHS R01 GM114140NIH HHS P40 OD010440
6 · The paper itself

Abstract

Six initially equivalent, multipotential Vulval Precursor Cells (VPCs) in

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationCell LineageCyclin-Dependent Kinase 8ErbB Receptorsets-Domain Protein Elk-1FemaleGenes, ReporterReceptors, NotchSignal TransductionTranscription FactorsTranscription, GeneticVulvaCaenorhabditis elegans ProteinsCyclin-Dependent Kinase 8ErbB Receptorsets-Domain Protein Elk-1Lin-12 protein, C elegansLin-1 protein, C elegansReceptors, NotchSur-2 protein, C elegansTranscription FactorsCdk8CDK-8C. elegansEGF receptorElk1LIN-1Med23NotchSUR-2vulva

Identifiers

PMID28954762
PMCPMC5714460
OpenAlexW2759102812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.