Evidence map›Paper›PMID 28954736›Full record

ArticleEndocrine connections2017

Interpretation of glucocorticoids in neonatal hair: a reflection of intrauterine glucocorticoid regulation?

Jonneke J Hollanders, Bibian van der Voorn, Noera Kieviet, Koert M Dolman, Yolanda B de Rijke, Erica L T van den Akker, Joost Rotteveel, Adriaan Honig, Martijn J J Finken

Open access · goldAbstract read
In one paragraph

Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  11. Absence of relationship between serum cortisol and critical illness in premature infants.Archives of disease in childhood. Fetal and neonatal edition · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jonneke J HollandersDepartment of Pediatric EndocrinologyVU University Medical Center, Amsterdam, The Netherlands j.hollanders@vumc.nl.
Bibian van der VoornDepartment of Pediatric EndocrinologyVU University Medical Center, Amsterdam, The Netherlands.
Noera KievietDepartment of PediatricsPsychiatry Obstetrics Pediatrics Expert Center, OLVG West, Amsterdam, The Netherlands.
Koert M DolmanDepartment of PediatricsPsychiatry Obstetrics Pediatrics Expert Center, OLVG West, Amsterdam, The Netherlands.
Yolanda B de RijkeDepartment of Clinical ChemistryErasmus MC, University Medical Center, Rotterdam, The Netherlands.
Erica L T van den AkkerDepartment of Pediatric EndocrinologyErasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
Joost RotteveelDepartment of Pediatric EndocrinologyVU University Medical Center, Amsterdam, The Netherlands.
Adriaan HonigDepartment of PediatricsPsychiatry Obstetrics Pediatrics Expert Center, OLVG West, Amsterdam, The Netherlands.
Martijn J J FinkenDepartment of Pediatric EndocrinologyVU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLErasmus MC · NLErasmus MC - Sophia Children’s Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlucocorticoids (GCs) measured in neonatal hair might reflect intrauterine as well as postpartum GC regulation. We aimed to identify factors associated with neonatal hair GC levels in early life, and their correlation with maternal hair GCs.

methodsIn a single-center observational study, mother-infant pairs (

results(1) Neonatal GC levels were >5 times higher than maternal levels, with a decrease in ±50% between birth and the OPV for cortisol. (2) Maternal and neonatal cortisol, but not cortisone, levels were correlated both at postpartum and at the OPV. (3) Gestational age was associated with neonatal GC postpartum (log-transformed

conclusionsNeonatal hair GCs mainly reflect the third trimester increase in cortisol, which might be caused by the positive feedback loop, a placenta-driven phenomenon, represented by the positive association with GA. Between birth and 1.5 months postpartum, neonatal hair cortisol concentrations decrease sharply, but still appear to reflect both intra- and extrauterine periods.

Indexed as

cortisolcortisonehair glucocorticoidsHPA axisinfantpositive feedback loop

Identifiers

PMID28954736
PMCPMC5655682
OpenAlexW2759349494

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.