Evidence map›Paper›PMID 28954569›Full record

ArticleJournal of biological rhythms2017

The Dorsal Medial Habenula Minimally Impacts Circadian Regulation of Locomotor Activity and Sleep.

Yun-Wei A Hsu, Jennifer J Gile, Jazmine G Perez, Glenn Morton, Miriam Ben-Hamo, Eric E Turner, Horacio O de la Iglesia

Open access · greenAbstract read
In one paragraph

Article in Journal of biological rhythms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yun-Wei A HsuCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Jennifer J GileDepartment of Biology and Graduate Program in Neuroscience, University of Washington, Seattle, Washington.
Jazmine G PerezDepartment of Biology and Graduate Program in Neuroscience, University of Washington, Seattle, Washington.
Glenn MortonCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Miriam Ben-HamoDepartment of Biology and Graduate Program in Neuroscience, University of Washington, Seattle, Washington.
Eric E TurnerCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Horacio O de la IglesiaDepartment of Biology and Graduate Program in Neuroscience, University of Washington, Seattle, Washington.
University of Washington · US

Funding

Putting habenula pathways on the mapR01MH093667 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI TURNER, ERIC E. · 2011 to 2019
$3.6M
Functional studies of the medial habenula in models of reward and mood disordersR01DA035838 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI TURNER, ERIC E. · 2014 to 2018
$2.1M
Role of GABA on circadian and homeostatic regulation of sleepR01NS094211 · NINDS · UNIVERSITY OF WASHINGTON · PI DE LA IGLESIA, HORACIO O · 2015 to 2018
$1.4M
Function of the Medial Habenula in Models of Anxiety and DepressionF32MH098498 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI HSU, YUN-WEI A · 2012 to 2013
$110k
NIDA NIH HHS R01 DA035838NIMH NIH HHS F32 MH098498NIMH NIH HHS R01 MH093667NINDS NIH HHS N01 NS002331NINDS NIH HHS R01 NS094211
6 · The paper itself

Abstract

In nocturnal rodents, voluntary wheel-running activity (WRA) represents a self-reinforcing behavior. We have previously demonstrated that WRA is markedly reduced in mice with a region-specific deletion of the transcription factor Pou4f1 (Brn3a), which leads to an ablation of the dorsal medial habenula (dMHb). The decrease in WRA in these dMHb-lesioned (dMHb

Indexed as

Circadian RhythmMotor ActivityAnimalsDarknessDepressionHabenulaLightLocomotionMicePeriod Circadian ProteinsPhotoperiodSleepSleep, REMSuprachiasmatic NucleusTranscription Factor Brn-3APer1 protein, mousePer2 protein, mousePeriod Circadian ProteinsPou4f1 protein, mouseTranscription Factor Brn-3Adepressionhabenulamotivationphysical activityREM sleepsleep

Identifiers

PMID28954569
PMCPMC5882496
OpenAlexW2758212365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.