ReviewEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2018
One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures.
Review in European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Assessment of ventilation heterogeneity and particle deposition in asthmatics using combined SPECT/CT imaging and computational modeling approaches.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025Article
- Subject-Specific Multi-Scale Modeling of the Fate of Inhaled Aerosols.Journal of aerosol science · 2025Article
- Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases.Pharmaceutics · 2024Review
- Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels.Scientific reports · 2023Article
- Fluid-structure interaction analysis of airflow, structural mechanics and aerosol dynamics in a four-generation acinar model.Journal of aerosol science · 2023Article
- A computed tomography imaging-based subject-specific whole-lung deposition model.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2022Article
- Microflows in two-generation alveolar cells at an acinar bifurcation.Biomicrofluidics · 2022Article
- Recent advances in the understanding of alveolar flow.Biomicrofluidics · 2022Review
- Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics.Advanced drug delivery reviews · 2021Review
- Airborne transmission of respiratory viruses.Science (New York, N.Y.) · 2021Review
- Focused targeting of inhaled magnetic aerosols in reconstructed in vitro airway models.Journal of biomechanics · 2021Article
- [Numerical simulation on the deposition characteristics of inhaled particles in human pulmonary acinus region under the influence of multi-factors].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Active pulmonary targeting against tuberculosis (TB) via triple-encapsulation of Q203, bedaquiline and superparamagnetic iron oxides (SPIOs) in nanoparticle aggregates.Drug delivery · 2019Article
- MultiscaleCurrent opinion in biomedical engineering · 2019Article
- Nanoparticle Deposition in Rhythmically Moving Acinar Models with Interalveolar Septal Apertures.Nanomaterials (Basel, Switzerland) · 2019Article
- Aerosol delivery into small anatomical airway model through spontaneous engineered breathing.Biomicrofluidics · 2019Article
- [Progress on numerical simulation of the deposition of inhaled particles in human pulmonary acinus region].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Review
- In Silico Methods for Development of Generic Drug-Device Combination Orally Inhaled Drug Products.CPT: pharmacometrics & systems pharmacology · 2019Review
- Use of computational fluid dynamics deposition modeling in respiratory drug delivery.Expert opinion on drug delivery · 2019Review
- How high resolution 3-dimensional imaging changes our understanding of postnatal lung development.Histochemistry and cell biology · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Computational Fluid Dynamics (CFD) have offered an attractive gateway to investigate in silico respiratory flows and aerosol transport in the depths of the lungs. Yet, not only do existing models lack sufficient anatomical realism in capturing the heterogeneity and morphometry of the acinar environment, numerical simulations have been widely restricted to domains capturing a mere few percent of a single acinus. Here, we present to the best of our knowledge the most detailed and comprehensive in silico simulations to date on the fate of aerosols in the acinar depths. Our heterogeneous acinar domains represent complete sub-acinar models (i.e. 1/8th of a full acinus) based on the recent algorithm of Koshiyama & Wada (2015), capturing statistics of human acinar morphometry (Ochs et al. 2004). Our simulations deliver high-resolution, 3D spatial-temporal data on aerosol transport and deposition, emphasizing how variances in acinar heterogeneity only play a minor role in determining general deposition outcomes. With such tools at hand, we revisit whole-lung deposition predictions (i.e. ICRP) based on past 1D lung models. While our findings under quiet breathing substantiate general deposition trends obtained with past predictions in the alveolar regions, we underscore how deposition fractions are anticipated to increase, in particular during deep inhalation. For such inhalation maneuver, our simulations support the notion of significantly augmented deposition for all aerosol sizes (0.005-5.0μm). Overall, our efforts not only help consolidate our mechanistic understanding of inhaled aerosol transport in the acinar depths but also continue to bridge the gap between "bottom-up" in silico models and regional deposition predictions from whole-lung models. Such quantifications provide what is deemed more accurate deposition predictions in morphometrically-faithful models and are particularly useful in assessing inhalation strategies for deep airway deposition (e.g. systemic delivery).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.