SynthesisPloS one2017
Performance of transient elastography and serum fibrosis biomarkers for non-invasive evaluation of recurrent fibrosis after liver transplantation: A meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Worldwide Review on the Performance of Non-Invasive Exhalation-Based Methods for the Diagnosis of Liver Fibrosis.International journal of environmental research and public health · 2026Pooled it
- Prospective comparison of an 18-gauge versus 16-gauge needle for percutaneous liver core-needle biopsy in children.Abdominal radiology (New York) · 2024Trial
- Screening and care of patients with graft cirrhosis following liver transplantation.Canadian liver journal · 2026Article
- Post-transplant MASLD: a risk-stratified approach to assessment and personalized management.Frontiers in medicine · 2026Review
- [Medical follow-up after solid organs transplantation].Innere Medizin (Heidelberg, Germany) · 2025Review
- Utilizing Machine Learning to Predict Liver Allograft Fibrosis by Leveraging Clinical and Imaging Data.Clinical transplantation · 2025Article
- Early diagnosis of liver graft steatosis and fibrosis: are non-invasive tests the answer?Translational gastroenterology and hepatology · 2025Article
- Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) after Liver Transplantation: A Narrative Review of an Emerging Issue.Journal of clinical medicine · 2024Review
- Harnessing Metabolites as Serum Biomarkers for Liver Graft Pathology Prediction Using Machine Learning.Metabolites · 2024Article
- Elevated Plasma CXCL8 Concentrations in Significant Fibrosis but Not in Subclinical Rejection After Adult Liver Transplantation.Transplantation direct · 2024Article
- Assessment of hepatic fibrosis with non-invasive indices in subjects with diabetes before and after liver transplantation.Frontiers in endocrinology · 2024Article
- Post-Transplant Hepatic Steatosis: A Condition Not to Overlook.Journal of clinical medicine · 2023Article
- A Comprehensive Review of Liver Allograft Fibrosis and Steatosis: From Cause to Diagnosis.Transplantation direct · 2023Review
- Non-Invasive Measurement of Hepatic Fibrosis by Transient Elastography: A Narrative Review.Viruses · 2023Review
- Quantification of extracellular matrix remodeling for the non-invasive identification of graft fibrosis after liver transplantation.Scientific reports · 2023Article
- Main factors influencing long-term outcomes of liver transplantation in 2022.World journal of hepatology · 2023Review
- Inevitability of disease recurrence after liver transplantation for NAFLD cirrhosis.JHEP reports : innovation in hepatology · 2023Article
- Development of a Radiomics-Based Model to Predict Graft Fibrosis in Liver Transplant Recipients: A Pilot Study.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Prospective comparison of liver stiffness measurement methods in surveillance biopsies after liver transplantation.Frontiers in transplantation · 2023Article
- Assessment of Liver Fibrosis with the Use of Elastography in Paediatric Patients with Diagnosed Cystic Fibrosis.Disease markers · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent fibrosis after liver transplantation (LT) impacts on long-term graft and patient survival. We performed a meta-analysis to compare the accuracy of non-invasive methods to diagnose significant recurrent fibrosis (stage F2-F4) following LT. Studies comparing serum fibrosis biomarkers, namely AST-to-platelet ratio index (APRI), fibrosis score 4 (FIB-4), or transient elastography (TE) with liver biopsy in LT recipients were systematically identified through electronic databases. In the meta-analysis, we calculated the weighted pooled odds ratio and used a fixed effect model, as there was no significant heterogeneity between studies. Eight studies were included for APRI, four for FIB-4, and twelve for TE. The mean prevalence of significant liver fibrosis was 37.4%. The summary odds ratio was significantly higher for TE (21.17, 95% CI confidence interval 14.10-31.77, p = 1X10-30) as compared to APRI (9.02, 95% CI 5.79-14.07; p = 1X10-30) and FIB-4 (7.08, 95% CI 4.00-12.55; p = 1.93X10-11). In conclusion, TE performs best to diagnose recurrent fibrosis in LT recipients. APRI and FIB-4 can be used as an estimate of significant fibrosis at centres where TE is not available. Longitudinal assessment of fibrosis by means of these non-invasive tests may reduce the need for liver biopsy.
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