Obesity: Receptors identified for a weight regulator.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.Oncoimmunology · 2025
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2. The landscape of immune therapy in vulnerable patients with advanced non-small cell lung cancer: a narrative review.Translational lung cancer research · 2023
   Review
3. The landscape of cancer cachexia in advanced non-small cell lung cancer: a narrative review.Translational lung cancer research · 2023
   Review
4. Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia.Cytokine & growth factor reviews · 2022
   Review
5. Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats.Journal of Parkinson's disease · 2021
   Article
6. Failure of Glial Cell-Line Derived Neurotrophic Factor (GDNF) in Clinical Trials Orchestrated By Reduced NR4A2 (NURR1) Transcription Factor in Parkinson's Disease. A Systematic Review.Frontiers in aging neuroscience · 2021
   Article
7. Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration.International journal of molecular sciences · 2020
   Review
8. CDNF Protein Therapy in Parkinson's Disease.Cell transplantation · 2019
   Article
9. Intestinal epithelial cell-specific Raptor is essential for high fat diet-induced weight gain in mice.Biochemical and biophysical research communications · 2018
   Article
10. The TGFβ superfamily in cardiac dysfunction.Acta biochimica et biophysica Sinica · 2018
    Review
11. Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine.Molecular pain
    Article

Corrections and comments

• Comment on
  GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.2017
• Comment on
  The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.2017
• Comment on
  GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.2017

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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