ArticleInternational journal of molecular sciences2017
Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Predictors of Multiple Sclerosis After Clinically Isolated Syndrome: A Systematic Review and Meta-Analysis.European journal of neurology · 2026Pooled it
- Prevalence of comorbid autoimmune diseases and antibodies in newly diagnosed multiple sclerosis patients.Neurological research and practice · 2024Article
- Clinical and paraclinical characteristics of optic neuritis in the context of the McDonald criteria 2017.Scientific reports · 2024Article
- Application of oligoclonal bands and other cerebrospinal fluid variables in multiple sclerosis and other neuroimmunological diseases: a narrative review.Annals of translational medicine · 2023Review
- CSF lymphocytic pleocytosis does not predict a less favourable long-term prognosis in MS.Journal of neurology · 2023Article
- Decreased Intrathecal Concentrations of Free Light Chains Kappa in Multiple Sclerosis Patients Taking Very High Effective Disease-Modifying Treatment.Diagnostics (Basel, Switzerland) · 2022Article
- The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid.Journal of central nervous system disease · 2021Review
- The Impact of Immunomodulatory Treatment on Kappa Free Light Chains as Biomarker in Neuroinflammation.Cells · 2020Article
- IgG Index Revisited: Diagnostic Utility and Prognostic Value in Multiple Sclerosis.Frontiers in immunology · 2020Article
- Reiber's Diagram for Kappa Free Light Chains: The New Standard for Assessing Intrathecal Synthesis?Diagnostics (Basel, Switzerland) · 2019Article
- Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis.Frontiers in neurology · 2019Review
- Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients.Frontiers in immunology · 2019Article
- The Persisting Significance of Oligoclonal Bands in the Dawning Era of Kappa Free Light Chains for the Diagnosis of Multiple Sclerosis.International journal of molecular sciences · 2018Article
- Advances in Multiple Sclerosis 2017.International journal of molecular sciences · 2018Article
- Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome.Frontiers in immunology · 2018Article
- Conversion of clinically isolated syndrome to multiple sclerosis: a prospective multi-center study in Eastern India.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Assessing the value of oligoclonal band count in multiple sclerosis: insights from a large cohort analysis.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the revised McDonald criteria of 2010 allow for the diagnosis of multiple sclerosis (MS) in an earlier stage, there is still a need to identify the risk factors for conversion to MS in patients with clinically isolated syndrome (CIS). Since the latest McDonald criteria were established, the prognostic role of cerebrospinal fluid (CSF) and visual evoked potentials (VEP) in CIS patients is still poorly defined. We conducted a monocentric investigation including patients with CIS in the time from 2010 to 2015. Follow-ups of 120 patients revealed that 42% converted to MS. CIS patients with positive oligoclonal bands (OCB) were more than twice as likely to convert to MS as OCB negative patients (hazard ratio = 2.6). The probability to develop MS was even higher when a quantitative intrathecal IgG synthesis was detected (hazard ratio = 3.8). In patients with OCB, VEP did not add further information concerning the conversion rate to MS. In patients with optic neuritis and negative OCB, a significantly higher rate converted to MS when VEP were delayed. In conclusion, the detection of an intrathecal IgG synthesis increases the conversion probability to MS. Pathological VEP can help to predict the conversion rate to MS in patients with optic neuritis without an intrathecal IgG synthesis.
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