Evidence map›Paper›PMID 28952963›Full record

ArticleJournal of neural engineering2018

Amorphous silicon carbide ultramicroelectrode arrays for neural stimulation and recording.

Felix Deku, Yarden Cohen, Alexandra Joshi-Imre, Aswini Kanneganti, Timothy J Gardner, Stuart F Cogan

Abstract read
In one paragraph

Article in Journal of neural engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  11. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
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  15. The Effect of Physical Structural Properties on Electrochemical Properties of Ruthenium Oxide for Neural Stimulating and Recording Electrodes.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024
    Article
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  17. Review
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  20. Charge Injection Enhancement Comparisons of Iridium Oxide MicroelectrodesInternational IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Felix DekuDepartment of Bioengineering, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, United States of America.ORCID 0000-0002-4915-1200
Yarden CohenDepartment of Biology and Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States of America.ORCID 0000-0002-8149-6954
Alexandra Joshi-ImreDepartment of Bioengineering, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, United States of America.
Aswini KannegantiDepartment of Bioengineering, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, United States of America.
Timothy J GardnerDepartment of Biology and Department of Biomedical Engineering, Boston University, Boston, MA 02215, United States of America.
Stuart F CoganDepartment of Bioengineering, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, United States of America.

Funding

High-Density Recording and Stimulating MicroelectrodesU01NS090454 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GARDNER, TIMOTHY JAMES · 2014 to 2016
$1.7M
NINDS NIH HHS U01 NS090454
6 · The paper itself

Abstract

objectiveForeign body response to indwelling cortical microelectrodes limits the reliability of neural stimulation and recording, particularly for extended chronic applications in behaving animals. The extent to which this response compromises the chronic stability of neural devices depends on many factors including the materials used in the electrode construction, the size, and geometry of the indwelling structure. Here, we report on the development of microelectrode arrays (MEAs) based on amorphous silicon carbide (a-SiC). APPROACH: This technology utilizes a-SiC for its chronic stability and employs semiconductor manufacturing processes to create MEAs with small shank dimensions. The a-SiC films were deposited by plasma enhanced chemical vapor deposition and patterned by thin-film photolithographic techniques. To improve stimulation and recording capabilities with small contact areas, we investigated low impedance coatings on the electrode sites. The assembled devices were characterized in phosphate buffered saline for their electrochemical properties. MAIN

resultsMEAs utilizing a-SiC as both the primary structural element and encapsulation were fabricated successfully. These a-SiC MEAs had 16 penetrating shanks. Each shank has a cross-sectional area less than 60 µm SIGNIFICANCE: The a-SiC MEAs provide a significant advancement in the development of microelectrodes that over the years has relied on silicon platforms for device manufacture. These flexible a-SiC MEAs have the potential for decreased tissue damage and reduced foreign body response. The technique is promising and has potential for clinical translation and large scale manufacturing.

Indexed as

Carbon Compounds, InorganicCoated Materials, BiocompatibleElectrodes, ImplantedSilicon CompoundsAnimalsBasal GangliaElectric StimulationFinchesMicroelectrodesMotor CortexRatsCarbon Compounds, InorganicCoated Materials, Biocompatiblesilicon carbideSilicon Compounds

Identifiers

PMID28952963
PMCPMC5786446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.