ArticleBioengineering (Basel, Switzerland)2017
Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors.
Article in Bioengineering (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genome-ReducedEngineering in life sciences · 2025Article
- Real Case Study of 600 mBiotechnology and bioengineering · 2025Article
- Integration Approaches to Model Bioreactor Hydrodynamics and Cellular Kinetics for Advancing Bioprocess Optimisation.Bioengineering (Basel, Switzerland) · 2024Review
- From Spatial-Temporal Multiscale Modeling to Application: Bridging the Valley of Death in Industrial Biotechnology.Bioengineering (Basel, Switzerland) · 2023Review
- Downscaling Industrial-Scale Syngas Fermentation to Simulate Frequent and Irregular Dissolved Gas Concentration Shocks.Bioengineering (Basel, Switzerland) · 2023Article
- An analysis of organism lifelines in an industrial bioreactor using Lattice-Boltzmann CFD.Engineering in life sciences · 2023Article
- Data-based dynamic compartment model: Modeling of E. coli fed-batch fermentation in a 600 m3 bubble column.Journal of industrial microbiology & biotechnology · 2022Article
- Optimization and Scale-Up of Fermentation Processes Driven by Models.Bioengineering (Basel, Switzerland) · 2022Review
- Synergistically applying 1-D modeling and CFD for designing industrial scale bubble column syngas bioreactors.Engineering in life sciences · 2020Article
- Flow-following sensor devices: A tool for bridging data and model predictions in large-scale fermentations.Computational and structural biotechnology journal · 2020Review
- Scale-Up Technologies for the Manufacture of Adherent Cells.Frontiers in nutrition · 2020Review
- In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models.Computational and structural biotechnology journal · 2018Review
- Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond.Microbial biotechnology · 2017Article
- Heterogeneity in Pure Microbial Systems: Experimental Measurements and Modeling.Frontiers in microbiology · 2017Review
- Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful scale-up of bioprocesses requires that laboratory-scale performance is equally achieved during large-scale production to meet economic constraints. In industry, heuristic approaches are often applied, making use of physical scale-up criteria that do not consider cellular needs or properties. As a consequence, large-scale productivities, conversion yields, or product purities are often deteriorated, which may prevent economic success. The occurrence of population heterogeneity in large-scale production may be the reason for underperformance. In this study, an
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Registered trials
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