Evidence map›Paper›PMID 28952490›Full record

ArticleBioengineering (Basel, Switzerland)2017

Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs.

Giovanny F Acosta-Vélez, Chase S Linsley, Madison C Craig, Benjamin M Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Computational approaches in bioprinting processes.Nature reviews bioengineering · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Giovanny F Acosta-VélezDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5531, Boelter Hall, P.O. Box: 951592, Los Angeles, CA 90095-1592, USA. gacosta3@g.ucla.edu.ORCID 0000-0002-7836-7617
Chase S LinsleyDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V, P.O. Box: 951600, Los Angeles, CA 90095, USA. clinsle@g.ucla.edu.
Madison C CraigDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V, P.O. Box: 951600, Los Angeles, CA 90095, USA. mcraig914@ucla.edu.
Benjamin M WuDepartment of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V, P.O. Box: 951600, Los Angeles, CA 90095, USA. benwu@g.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs.

Indexed as

3D printinghyaluronic acidinkjet printingnorbornenepharmaceutical tabletsRopinirole

Identifiers

PMID28952490
PMCPMC5590429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.