ArticleInternational journal of hematology2018
Persistent changes in circulating white blood cell populations after splenectomy.
Article in International journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Vaccinations in Pediatric Hematology and Oncology: Biologic Basis, Clinical Applications, and Perspectives.Vaccines · 2025Review
- Leukocytosis and thrombocytosis after splenectomy: expected finding, infection, or something else: a case report.Journal of medical case reports · 2024Article
- Germline mutations in a G protein identify signaling cross-talk in T cells.Science (New York, N.Y.) · 2024Article
- A functional spleen contributes to afucosylated IgG in humans.Scientific reports · 2021Article
- Role of Partial Splenectomy in Hematologic Childhood Disorders.Pathogens (Basel, Switzerland) · 2021Review
- Changes in peripheral lymphocyte populations in patients with advanced/recurrent ovarian cancer undergoing splenectomy during cytoreductive surgery.Journal of ovarian research · 2021Article
- Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study.BMC surgery · 2020Article
- Immune thrombocytopenic purpura risk by live, inactivated and simultaneous vaccinations among Japanese adults, children and infants: a matched case-control study.International journal of hematology · 2020Article
- High-Dimensional Analysis of Postsplenectomy Peripheral Immune Cell Changes.ImmunoHorizons · 2020Article
- Post-splenectomy Sepsis: A Review of the Literature.Cureus · 2020Review
- Predictive Factors for Platelet Count Variation After Splenectomy in Non-Traumatic Diseases.Journal of clinical medicine · 2019Article
- Post-splenectomy sepsis: preventative strategies, challenges, and solutions.Infection and drug resistance · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of splenectomy on the incidence of infections and thromboembolisms has been investigated thoroughly. Nevertheless, the long-term effects of splenectomy on immunological profile and circulating blood counts have not been described before. To study such long-term effects, we analysed several parameters in splenectomised trauma patients and compared the results of this group ("otherwise healthy patients") to patients with a specific underlying disease. We measured platelet count, leukocytes and differential, lymphocyte subsets, serum levels of immunoglobulins, and complement pathways in 113 patients. Indications to perform a splenectomy were trauma (n = 42), Hodgkin lymphoma (n = 24), hereditary spherocytosis (n = 21), and immune thrombocytopenia (n = 26). In trauma patients lymphocytes and lymphocytes subsets were particularly elevated compared to normal population values. Splenectomised patients with Hodgkin lymphoma had significant lower numbers of T lymphocytes than trauma patients. Significant increases in platelets, leukocytes, and monocytes were observed in patients with hereditary spherocytosis. Occurrence of MBL genotype was different in ITP patients than in other splenectomised groups and the normal population. In splenectomised patients (> 4 years), platelet counts and lymphocyte subsets are increased which persist over time. As a result, these blood counts in splenectomised patients differ from reference values in the normal population.
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