Evidence map›Paper›PMID 28952069›Full record

ArticleInflammation2018

Anti-IL-33 Antibody Has a Therapeutic Effect in an Atopic Dermatitis Murine Model Induced by 2, 4-Dinitrochlorobenzene.

Ge Peng, Zhenzhen Mu, Lixia Cui, Pengyue Liu, Ying Wang, Wenqing Wu, Xiuping Han

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. IL-33/IL-31 Axis in Immune-Mediated and Allergic Diseases.International journal of molecular sciences · 2019
    Pooled it
  2. Trial
  3. Review
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  7. Article
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  9. Article
  10. Article
  11. Article
  12. Review
  13. Nutrients · 2022
    Article
  14. Eosinophilic esophagitis: Immune mechanisms and therapeutic targets.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  15. Article
  16. IL-33 signaling in sensory neurons promotes dry skin itch.The Journal of allergy and clinical immunology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ge PengDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China.
Zhenzhen MuDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China.
Lixia CuiDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China.
Pengyue LiuDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China.
Ying WangDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China.
Wenqing WuDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China.
Xiuping HanDepartment of Dermatology, Shengjing Hospital of China Medical University, No. 36 Sanhao St., Heping Area, Shenyang, Liaoning, 110004, China. hanxiuping66@126.com.ORCID http://orcid.org/0000-0003-1228-0436
China Medical University · CN

Funding

Science and Technology Project of Shenyang 17-230-9-25Scientific Research General Project of Educational Department in Liaoning Province of China in 2014 L2014295
6 · The paper itself

Abstract

IL-33 is a new member of the IL-1 family that plays a role in allergic disease. In this study, we evaluated the potential on the inhibition of atopic dermatitis (AD) of anti-mouse IL-33 antibody (αIL-33Ab) using 2, 4-dinitrochlorobenzene (DNCB)-induced AD mice model. We treated mice with αIL-33Ab via subcutaneous injection of each DNCB treatment 1 h later from day 1 to day 33 for 14 times. A control group received tacrolimus. Skin lesion and scratching behavior were compared. Ear thickness, dermatitis score, eosinophils and mast cells infiltration, and serum IgE levels were also analyzed. Correlations between serum IL-33 as well as soluble(s) ST2 and AD disease activity index in human AD were also investigated. DNCB-induced AD-like mice treated with αIL-33Ab showed improved AD-like symptoms. Eosinophils and mast cells infiltration and serum IgE levels were also significantly reduced by αIL-33Ab. Our study suggests that blockade of IL-33 has a curative effect on AD.

Indexed as

DinitrochlorobenzeneAdolescentAdultAnimalsAnti-Allergic AgentsAntibodiesCase-Control StudiesChemotaxisChildChild, PreschoolDermatitis, AtopicDisease Models, AnimalEosinophilsFemaleHumansImmunoglobulin EAnti-Allergic AgentsAntibodiesDinitrochlorobenzeneIL1RL1 protein, humanIL33 protein, humanIl33 protein, mouseImmunoglobulin EInterleukin-1 Receptor-Like 1 ProteinInterleukin-33atopic dermatitisDNCBIL-33inhibitionαIL-33Ab

Identifiers

PMID28952069
OpenAlexW2759289413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.