ArticleAbdominal radiology (New York)2018
Uterine fibroids: correlations between MRI appearance and stiffness via magnetic resonance elastography.
Article in Abdominal radiology (New York), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Magnetic resonance elastography (MRE) for the evaluation of fibrosis in patients with benign uterine disorders: a systematic review.Abdominal radiology (New York) · 2026Pooled it
- The Role of Interventional Radiology in the Diagnosis and Treatment of Gynecological Conditions.Tomography (Ann Arbor, Mich.) · 2026Review
- Overcoming Mechanical Blindness: Adaptive Surgical Instrument Design for the Heterogeneous Landscape of Uterine Fibroids.Research (Washington, D.C.) · 2026Review
- Article
- 3D vector MR elastography applications in small organs.Magnetic resonance imaging · 2024Review
- Multiparametric quantitative magnetic resonance imaging of uterine fibroids for prediction of growth rate-a pilot study.Quantitative imaging in medicine and surgery · 2024Article
- Postprandial splenic stiffness changes on magnetic resonance elastography in a young healthy population.NMR in biomedicine · 2024Article
- Evaluation of Spleen Stiffness in Young Healthy Volunteers Using Magnetic Resonance Elastography.Diagnostics (Basel, Switzerland) · 2023Article
- Prevention of Uterine Fibroids: molecular mechanisms and potential clinical application.Journal of endometriosis and uterine disorders · 2023Article
- Biological role of matrix stiffness in tumor growth and treatment.Journal of translational medicine · 2022Review
- Advances in the clinical application of ultrasound elastography in uterine imaging.Insights into imaging · 2022Review
- Uterine bleeding: how understanding endometrial physiology underpins menstrual health.Nature reviews. Endocrinology · 2022Review
- Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids-Efficiency Assessment with the Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and the Potential Role of the Administration of Uterotonic Drugs.Diagnostics (Basel, Switzerland) · 2021Article
- The Advance of Magnetic Resonance Elastography in Tumor Diagnosis.Frontiers in oncology · 2021Review
- Clinical experience of robotic myomectomy for fertility preservation using preoperative magnetic resonance imaging predictor.Obstetrics & gynecology science · 2020Article
- Uterine leiomyomas: correlation between histologic composition and stiffness via magnetic resonance elastography - a Pilot Study.Ginekologia polska · 2020Article
- Biomarkers in abnormal uterine bleeding†.Biology of reproduction · 2019Review
- Moving Toward Individualized Medicine for Uterine Leiomyomas.Obstetrics and gynecology · 2018Article
- New and Emerging Applications of Magnetic Resonance Elastography of Other Abdominal Organs.Topics in magnetic resonance imaging : TMRI · 2018Review
- Ultrasonography of uterine leiomyomas.Przeglad menopauzalny = Menopause review · 2017Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesMagnetic resonance elastography has proven to be a valuable tool in the diagnosis of liver fibrosis, breast and cervical cancer, but its application in uterine fibroids requires further characterization. The aim of the present study was to examine the relationship between uterine fibroid stiffness by MRE and MR imaging characteristics. MATERIALS AND
methodsAn IRB-approved, HIPAA compliant review was performed of prospectively collected pelvic MRI and 2D-MRE data in patients with symptomatic uterine fibroids (N = 102). T1 and T2 weighted pelvic MRI with gadolinium enhancement were performed. In a small patient subset, fibroid stiffness was assessed by both 2D and 3D MRE. Fibroid stiffness by modality or imaging characteristics was analyzed using one-way analysis of variance followed by Student t test.
resultsFour fibroid groups were identified based on T2 appearance: Isointense (N = 7), bright (N = 6), dark with minimal heterogeneity (N = 69), and dark with substantial heterogeneity (N = 20). Mean fibroid stiffness was 4.81 ± 2.12 kPa. Comparison of fibroid stiffness by T2 signal intensity showed that T2 bright fibroids were significantly less stiff than fibroids appearing T2 dark with minimal heterogeneity (mean stiffness difference = 2.38 kPa; p < 0.05) and T2 dark fibroids with substantial heterogeneity were significantly less stiff than T2 dark fibroids with minimal heterogeneity (mean difference = 1.25 kPa; p < 0.05). There was no significant association between fibroid stiffness and T1 signal characteristics or gadolinium enhancement. There was no significant difference in stiffness values obtained by either 2D vs. 3D MRE.
conclusionsThese data suggest differences in fibroid stiffness are associated with different T2 imaging characteristics with less stiff fibroids being T2 bright and more stiff fibroids being T2 dark. Further studies are needed to determine if fibroid stiffness by MRE may serve as an imaging biomarker to help predict MR-guided treatment response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.