Evidence map›Paper›PMID 28951977›Full record

ReviewJournal of assisted reproduction and genetics2018

Polycystic ovary syndrome throughout a woman's life.

José Bellver, Luis Rodríguez-Tabernero, Ana Robles, Elkin Muñoz, Francisca Martínez, José Landeras, Juan García-Velasco, Juan Fontes, Mónica Álvarez, Claudio Álvarez and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 180 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Visceral adiposity and insulin resistance in polycystic ovarian syndrome - A cross-sectional, observational study.European journal of obstetrics & gynecology and reproductive biology: X · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

José BellverIVI-Valencia, University of Valencia, Valencia, Spain. jose.bellver@ivi.es.
Luis Rodríguez-TaberneroHospital Clínico Universitario, Valladolid, Spain.
Ana RoblesHospital del Mar, Barcelona, Spain.
Elkin MuñozIVI-Vigo, Vigo, Spain.
Francisca MartínezSalud de la Mujer, Hospital Universitario Dexeus, Barcelona, Spain.
José LanderasIVI-Murcia, Murcia, Spain.
Juan García-VelascoIVI-Madrid, Rey Juan Carlos University, Madrid, Spain.
Juan FontesHospital Virgen de las Nieves, Granada, Spain.
Mónica ÁlvarezHospital Materno Infantil, Las Palmas, Spain.
Claudio ÁlvarezURE Centro Gutenberg, Málaga, Spain.
Belén AcevedoFundación Jiménez Díaz, Madrid, Spain.
Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF)
Hospital Del Mar · ESHospital Universitario Dexeus · ESHospital Universitario Fundación Jiménez Díaz · ESUniversidad Rey Juan Carlos · ESHospital Materno-Infantil · ESHospital Universitario Virgen de las Nieves · ESUniversitat de València · ESValencian Infertility Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age. Menstrual and fertility problems evolve into metabolic complications as age advances. An early and precise diagnosis is important for an adequate management of PCOS, especially at the extreme ends of the reproductive lifespan. However, many different phenotypes are included under the same condition, being important to look at these different phenotypes separately, as they may require different treatments and have different consequences. In this way, PCOS exhibits a great metabolic complexity and its diagnosis needs to be revised once again and adapted to recent data obtained by new technologies. According to the current medical literature, lifestyle therapy constitutes the first step in the management, especially when excess body weight is associated. Pharmacotherapy is frequently used to treat the most predominant manifestations in each age group, such as irregular menses and hirsutism in adolescence, fertility problems in adulthood, and metabolic problems and risk of cancer in old age. Close surveillance is mandatory in each stage of life to avoid health risks which may also affect the offspring, since fetal and post-natal complications seem to be increased in PCOS women.

Indexed as

AdolescentAdultFemaleGrowth and DevelopmentHumansMiddle AgedPolycystic Ovary SyndromeReproductionSexual MaturationYoung AdultAdolescenceChildhoodFertilityPerimenopausePolycystic ovary syndromePregnancy complications

Identifiers

PMID28951977
PMCPMC5758469
OpenAlexW2758457511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.