Evidence map›Paper›PMID 28951942›Full record

ArticleClinical neuroradiology2019

Proton Density Fat Suppressed MRI in 3T Increases the Sensitivity of Multiple Sclerosis Lesion Detection in the Cervical Spinal Cord.

Efstratios Karavasilis, George Velonakis, George Argiropoulos, Athanasios Athanasakos, Loukia S Poulou, Panagiotis Toulas, Nikolaos L Kelekis, Efstathios P Efstathopoulos

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In one paragraph

Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Efstratios KaravasilisSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. stratoskaravasilis@yahoo.gr.ORCID http://orcid.org/0000-0002-7291-2231
George VelonakisSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
George ArgiropoulosSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Athanasios AthanasakosSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Loukia S PoulouSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis ToulasSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos L KelekisSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Efstathios P EfstathopoulosSecond Department of Radiology, University General Hospital 'Attikon', School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConsidering the number of multiple sclerosis (MS) patients referred for clinical spinal cord imaging, the optimization of imaging protocols plays a crucial role. We aimed to evaluate the use of proton density (PD) turbo spin-echo (TSE) with spectral attenuated inversion recovery (SPAIR) fat suppression and compare it with the currently recommended T2-TSE-SPAIR in sagittal plane in cervical spinal cord imaging.

methodsIn this study 35 MS patients with clinically suspected or known spinal cord lesions were scanned on a 3.0T magnetic resonance imaging (MRI) system. In addition to the routine protocol, PD-TSE-SPAIR sequences were obtained to quantitatively and qualitatively evaluate lesion detectability and image quality compared to T2-TSE-SPAIR sequences. Quantitative analysis was based on measurements of lesion-to-cord contrast ratio (LCCR), lesion contrast-to-noise ratio (LCNR) and lesion dimensions and the qualitative analysis on ranking with a predetermined score scale. The presence of lesions in these sequences was verified in axial T2 multi-echo gradient echo images.

resultsIn quantitative analysis, the lesions on PD-TSE-SPAIR had statistically significantly higher contrast (p < 0.05), according to the statistical test of LCCR, LCNR calculated contrast and measured lesion dimensions. Qualitative analyses were congruent with quantitative results; the median rank of PD-TSE-SPAIR was significantly higher than T2-TSE-SPAIR (p < 0.05). Of the 34 detected lesions 9 (26%) were not visualized in T2-TSE-SPAIR sequence.

conclusionConsidering its superiority in contrast ratios and lesion dimensions when compared to T2-TSE-SPAIR in both qualitative and quantitative analyses, we therefore recommend PD-TSE-SPAIR as a pivotal sequence to evaluate demyelinating spinal cord lesions at 3T.

Indexed as

AdultFemaleHumansMagnetic Resonance ImagingMaleMultiple SclerosisMyelin SheathSensitivity and SpecificitySignal-To-Noise RatioSpinal CordSpinal Cord DiseasesStatistics, NonparametricCervical spinal cordMagnetic resonanceMultiple sclerosis

Identifiers

PMID28951942
OpenAlexW2758592486

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