ArticleBioMed research international2017
Heterogeneity of Necrotic Changes between Cortical and Cancellous Bone in Mandibular Osteoradionecrosis: A Histopathological Analysis of Resection Margin after Segmental Mandibulectomy.
Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Prevalence of free flap failure in mandibular osteoradionecrosis reconstruction: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Effectiveness of a protocol with antimicrobial photodynamic therapy for treating osteoradionecrosis: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Relationship between bone union and degree of bone marrow fibrosis at resection margins of advanced mandibular ORN.Clinical oral investigations · 2024Article
- Bone turnover biomarkers reflect radiation-induced bone injuries in women with non-metastatic rectal cancer.JBMR plus · 2024Article
- Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Article
- Factors Associated with Treatment Outcomes and Pathological Features in Patients with Osteoradionecrosis: A Retrospective Study.International journal of environmental research and public health · 2022Article
- Article
- Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma.Radiation oncology (London, England) · 2021Article
- Bacterial Colonization of the Condyle in Patients with Advanced Mandibular Osteoradionecrosis: Analysis of Hemimandibulectomy Specimens.International journal of dentistry · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis.
methodsAnteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneous free fibula flap reconstruction for advanced osteoradionecrosis were analyzed histopathologically for the presence of necrotic bone based on the presence of blood vessels within Haversian canals.
resultsTen of eleven (91%) cortices near the inferior border of the mandible at the anterior margins were necrotic. All cancellous bones at the anterior margins were viable. Seven of eleven (64%) cortices near the inferior border of the mandible at the posterior margins were necrotic. Three of eleven (27%) cancellous bones at the posterior margins were necrotic.
conclusionNecrotic changes are more prevalent in cortices than in cancellous bones in mandibular osteoradionecrosis, probably due to a decrease of periosteal blood supply caused by radiotherapy.
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