ArticleIntegrative medicine research2017
Study on pharmacokinetics and tissue distribution of single dose oral tryptanthrin in Kunming mice by validated reversed-phase high-performance liquid chromatography with ultraviolet detection.
Article in Integrative medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 24 citations in OpenAlex.
- Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice.Journal of applied toxicology : JAT · 2026Article
- Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats.Bulletin of experimental biology and medicine · 2024Article
- Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals.Science advances · 2022Article
- Cancer Chemoprevention: A Strategic Approach Using Phytochemicals.Frontiers in pharmacology · 2021Review
- Poricoic acid A as a modulator of TPH-1 expression inhibits renal fibrosisTherapeutic advances in chronic disease · 2020Article
- Construction and in vivoInternational journal of nanomedicine · 2019Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundTryptanthrin is a major active constituent of several Chinese herbal plants, such as
methodsIn this study, the pharmacokinetics (PK) and tissue distribution of tryptanthrin in Kunming mice following a single oral dose of 80 mg/kg tryptanthrin were investigated for the first time. Mouse plasma, liver, heart, spleen, lung, kidney and brain were collected and analyzed using a validated reversed-phase high-performance liquid chromatography with ultraviolet detection (RP-HPLC-UV) method after biological sample preparation by a simple liquid-liquid extraction.
resultsThe chromatographic analysis was performed on a Diamonsil C
conclusionIn this study, a validated RP-HPLC-UV method was developed and successfully applied to PK and tissue distribution of oral tryptanthrin in mice. We confirmed that tryptanthrin was closely related and targeted to plasma, liver, kidney, and lung. These results indicate that tryptanthrin will have a good clinical application in the liver, kidney, or lung. The clinical use of tryptanthrin should focus on its pharmacodynamics and safety study in these tissues.
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