ReviewMolecular metabolism2017
Intraocular
Review in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Reprogramming of Different Cell Lineages into Functional β-Cell Substitutes.Cellular reprogramming · 2025Review
- Glucose-Stimulated Insulin Secretion via Perfusion through the Mice Vasculature with an Intact Pancreas.Journal of visualized experiments : JoVE · 2025Article
- Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function.Nature communications · 2024Article
- Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors.Communications biology · 2023Article
- Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype ofMetabolites · 2021Article
- Alpha cell regulation of beta cell function.Diabetologia · 2020Review
- Functional analysis of islet cells in vitro, in situ, and in vivo.Seminars in cell & developmental biology · 2020Review
- Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours.Scientific reports · 2019Article
- A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo.Scientific reports · 2019Article
- The eye as a novel imaging site in diabetes research.Pharmacology & therapeutics · 2019Review
- Modelling the endocrine pancreas in health and disease.Nature reviews. Endocrinology · 2019Review
- Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Pancreatic Progenitors: There and Back Again.Trends in endocrinology and metabolism: TEM · 2019Review
- A Review of the Emerging Role of Silk for the Treatment of the Eye.Pharmaceutical research · 2018Review
- In vivo monitoring of intracellular CaIslets · 2018Article
- Local Dexamethasone Administration Delays Allogeneic Islet Graft Rejection in the Anterior Chamber of the Eye of Non-Human Primates.Cell transplantationArticle
- Challenges in stem cell-derived islet replacement therapy can be overcome.Cell transplantationArticle
- Islet Transplantation to the Anterior Chamber of the Eye-A Future Treatment Option for Insulin-Deficient Type-2 Diabetics? A Case Report from a Nonhuman Type-2 Diabetic Primate.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus has reached epidemic proportions and requires new strategies for treatment. Unfortunately, the efficacy of treatment regimens on maintaining/re-gaining functional beta cell mass can, at the present, only be determined indirectly. Direct monitoring of beta cell mass is complicated by the anatomy of the endocrine pancreas, which consists of thousands to a million of discrete micro-organs, i.e. islets of Langerhans, which are scattered throughout the pancreas. SCOPE OF REVIEW: Here, we review the progress made over the last years using the anterior chamber of the eye as a transplantation site for functional imaging of pancreatic islet cells in the living organism. Islets engrafted on the iris are vascularized and innervated and the cornea, serving as a natural body-window, allows for microscopic, non-invasive, longitudinal evaluation of islet/beta cell function and survival with single-cell resolution in health and disease. MAJOR
conclusionsData provided by us and others demonstrate the high versatility of this imaging platform. The use of 'reporter islets' engrafted in the eye, reporting on the status of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.