ArticleInternational journal of physiology, pathophysiology and pharmacology2017
The effect of epigallocatechin-3-gallate on the renal dysfunction in the obstructed kidney in the rat.
Article in International journal of physiology, pathophysiology and pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Carvacrol attenuated acute renal injury induced by unilateral ureteral obstruction in male rats.Iranian journal of basic medical sciences · 2026Article
- Mechanisms of the Effects of Polyphenols on Diabetic Nephropathy.Current issues in molecular biology · 2025Review
- The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular Senescence.International journal of molecular sciences · 2024Review
- The long-term renal effects of short periods of unilateral ureteral obstruction.International journal of physiology, pathophysiology and pharmacology · 2022Review
- Catechins: Therapeutic Perspectives in COVID-19-Associated Acute Kidney Injury.Molecules (Basel, Switzerland) · 2021Review
- Epigallocatechin-3-gallate ameliorates LPS-induced inflammation by inhibiting the phosphorylation of Akt and ERK signaling molecules in rat H9c2 cells.Experimental and therapeutic medicine · 2020Article
- Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model.Stem cell research & therapy · 2020Article
- The Effect of Arabic Gum on Renal Function in Reversible Unilateral Ureteric Obstruction.Biomolecules · 2019Article
- Does β-caryophyllene protect against renal dysfunction following ischemia-reperfusion injury in the rat?International journal of physiology, pathophysiology and pharmacology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpigallocatechin-3-gallate (EGCG) is the most active catechin polyphenol extracted from the green tea. EGCG has protective effects in various renal and non-renal conditions. The aim of this study was to investigate the effect of EGCG on the alterations in renal functional parameters following reversible unilateral ureteral obstruction (UUO) in the rat.
methodsWistar rats underwent reversible left UUO for 72 hours. Group-EGCG (n=10) received intraperitoneal 50 mg/kg/day of EGCG whereas Group-Vx (n=10) had only normal saline. Five days post UUO reversal, renal functions of both kidneys were measured using clearance techniques and the gene expression of some of kidney injury markers (KIM-1 and NGL) and the pro-inflammatory mediator (TNF-α) were determined using real time PCR.
resultsRenal blood flow, glomerular filtration rate, urine volume and urinary sodium excretion were still altered 5 days post-UUO reversal. Fractional sodium excretion had returned to baseline values by that time. EGCG did not significantly affect any of the renal functional parameters of the obstructed kidney (P>0.05 for all). However, it significantly decreased the gene expressions of KIM-1, NGAL and TNF-α in the left obstructed kidney in Group-EGCG compared to Group-Vx (28±27 vs. 286±107, 1.1±0.2 vs. 10.9±4.3, and 0.8±0.1 vs. 1.5±0.2, P<0.05 for all).
conclusionEGCG appears to have no significant protective effect on the haemodynamic or tubular glomerular functions when measured as early as five days post reversal of UUO despite the attenuation of some of the kidney injury markers and pro-inflammatory mediators.
Indexed as
Identifiers
28951774PMC5592246W2987479058What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.