Evidence map›Paper›PMID 28951731›Full record

ArticleFrontiers in immunology2017

Minimal Sex-Differential Modulation of Reactivity to Pathogens and Toll-Like Receptor Ligands following Infant Bacillus Calmette-Guérin Russia Vaccination.

Fatoumatta Darboe, Jane U Adetifa, John Reynolds, Safayet Hossin, Magdalena Plebanski, Mihai G Netea, Sarah L Rowland-Jones, Jayne S Sutherland, Katie L Flanagan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Fatoumatta DarboeVaccines and Immunity Theme, MRC Unit, Fajara, Gambia.
Jane U AdetifaVaccines and Immunity Theme, MRC Unit, Fajara, Gambia.
John ReynoldsBiostatistics Consulting Platform, Faculty of Medicine, Nursing and Health Sciences, Monash University, Prahran, VIC, Australia.
Safayet HossinVaccines and Immunity Theme, MRC Unit, Fajara, Gambia.
Magdalena PlebanskiDepartment of Immunology and Pathology, Monash University, Prahran, VIC, Australia.
Mihai G NeteaDepartment of Internal Medicine, Radboud Center for Infectious Diseases, Nijmegen University Nijmegen Medical Center, Nijmegen, Netherlands.
Sarah L Rowland-JonesVaccines and Immunity Theme, MRC Unit, Fajara, Gambia.
Jayne S SutherlandVaccines and Immunity Theme, MRC Unit, Fajara, Gambia.
Katie L FlanaganVaccines and Immunity Theme, MRC Unit, Fajara, Gambia.
MRC Unit the Gambia · GMMonash Institute of Medical Research · AUMonash University · AUUniversity of Oxford · GBUniversity of Tasmania · AU

Funding

European Research Council 310372Medical Research Council G0701291Medical Research Council MC_U190071468Medical Research Council MC_U190085854
6 · The paper itself

Abstract

Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis, has been shown to provide heterologous protection against unrelated pathogens and enhance antibody responses to several routine expanded program on immunization (EPI) vaccines. Understanding these heterologous effects is important for the development of optimal vaccination strategies. We set out to assess the effect of vaccination with BCG Russia of 6-week-old infants on

Indexed as

adaptive immunitycytokinesheterologous effectsinnate immunitynon-specific effectstoll-like receptorsvaccine

Identifiers

PMID28951731
PMCPMC5599783
OpenAlexW2752103507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.