Evidence map›Paper›PMID 28951698›Full record

ArticleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Dependence of micronuclei assay on the depth of absorbed dose.

Seyed Mohammad Mahdi Abtahi, Seyed Mahmoud Reza Aghamiri, Masoumeh Yadolahi, Aziz Mahmoudzadeh

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Article in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Seyed Mohammad Mahdi AbtahiPhysics Department, Imam Khomeini International University, Norouzian, P.O. Box 34148-96818, Qazvin, Iran.
Seyed Mahmoud Reza AghamiriRadiation Medicine Department, University of Shahid Beheshti, Tehran, Iran.
Masoumeh YadolahiNursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Aziz MahmoudzadehDepartment of Bioscience and Biotechnology, Malek-Ashtar University of Technology, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose.

backgroundOne of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN). Being less complex and faster than other methods are two remarkable advantages of the MN method which make it suitable for monitoring of population. In biological dosimetry based on the micronuclei method, the investigation into the dependence of response on the depth in which dose is absorbed is significant, though has received less attention so far. MATERIALS AND

methodsBlood samples were poured in separate vials to be irradiated at different depths using a linear accelerator system.

resultsAccording to the results, MN, as a function of the absorbed dose, had the best fitness with the linear-quadratic model at all depths. Furthermore, the results showed the dependence of MN response on the depth of absorbed dose. For doses up to 2 Gy, the maximum difference from the reference depth of 1.5 cm was related to the depth of 10 cm; however, by increasing the absorbed dose, the response associated with the depth of 20 cm showed the maximum deviation from the reference depth.

conclusionsConsequently, it is necessary to apply a correction factor to the biological dosimetry. The correction factor is dependent on the depth and the absorbed dose.

Indexed as

Biological dosimetryBloodCorrection factorGamma radiationMicronuclei

Identifiers

PMID28951698
PMCPMC5605490

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