Evidence map›Paper›PMID 28951620›Full record

ArticleScientific reports2017

Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes.

Rongrong Cai, Rong Huang, Jing Han, Haixia Sun, Jie Sun, Wenqing Xia, Sai Tian, Xue Dong, Yanjue Shen, Shaohua Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Rongrong CaiDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
Rong HuangDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
Jing HanDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
Haixia SunDepartment of Endocrinology, Yixing People's Hospital, Yixing, China.
Jie SunDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
Wenqing XiaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Sai TianDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
Xue DongDepartment of Endocrinology, Wuxi No.2 People's Hospital, Wuxi, China.
Yanjue ShenDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China.
Shaohua WangDepartment of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, China. gyjwsh@163.com.
Zhongda Hospital Southeast University · CNNanjing Medical University · CNWuxi No.2 People's Hospital · CNYixing People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a low-grade chronic inflammatory diseases, which have been implicated in the pathogenesis of cognitive decline. We aim to evaluate associations between inflammatory markers and the risk of mild cognitive impairment (MCI) in T2DM. This study of 140 diabetic patients involved 71 with MCI and 69 controls. Clinical parameters, neuropsychological tests, high sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6), lipoprotein-associated Phospholipase A2 (Lp-PLA2) mass and activity were measured. The results showed significantly higher plasma hsCRP, IL-6, Lp-PLA2 mass and activity in MCI group compared to controls. In T2DM with MCI, the Montreal Cognitive Assessment (MoCA) score was positively correlated with education level and high-density lipoprotein cholesterol (HDL-c), but inversely correlated with age, glycosylated hemoglobin, intima-media thickness (IMT), hsCRP, IL-6, and Lp-PLA2 mass and activity. Correlation analysis showed that both plasma Lp-PLA2 mass and activity were positively correlated with total cholesterol, low-density lipoprotein cholesterol, and IMT but negatively associated with MoCA score. Multivariable logistic regression analysis indicated higher hsCRP, Lp-PLA2 mass, Lp-PLA2 activity, and lower HDL-c to be independent risk factors increasing the possibility of MCI in T2DM. In conclusion, plasma Lp-PLA2 and hsCRP were found to be associated with the risk of MCI among T2DM patients.

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseAdultAgedAsian PeopleBiomarkersCase-Control StudiesCognitive DysfunctionC-Reactive ProteinDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedRisk Factors1-Alkyl-2-acetylglycerophosphocholine EsteraseBiomarkersC-Reactive ProteinPLA2G7 protein, human

Identifiers

PMID28951620
PMCPMC5615059
OpenAlexW2754037734

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.