Evidence map›Paper›PMID 28951579›Full record

ReviewNature reviews. Gastroenterology & hepatology2017

Expert consensus document: Advances in the management of oesophageal motility disorders in the era of high-resolution manometry: a focus on achalasia syndromes.

Peter J Kahrilas, Albert J Bredenoord, Mark Fox, C Prakash Gyawali, Sabine Roman, André J P M Smout, John E Pandolfino, International Working Group for Disorders of Gastrointestinal Motility and Function

Erratum issued Registry-linked trialOpen access · hybridAbstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06290882 (Endoscopic Versus Robotic Myotomy for Treatment of Achalasia), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06290882 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Endoscopic Versus Robotic Myotomy for Treatment of Achalasia (ERMA Trial)

TypeinterventionalSponsorGermans Trias i Pujol HospitalRan2024 to 2027Enrolled144ConditionsAchalasia CardiaArmsRobotic Heller Myotomy, Peroral Endoscopic Myotomy
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Guideline
  2. Achalasia: Physician Practices and Knowledge in Türkiye.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Article
  3. Review
  4. Article
  5. Late Onset of Pseudoachalasia in Anti-Hu-Associated Syndrome.Case reports in gastrointestinal medicine · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Achalasia cardia sub-types in children: Does it affect the response to therapy?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Chicago classification version 4.0Neurogastroenterology and motility · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Peter J KahrilasNorthwestern University, Feinberg School of Medicine, Department of Medicine, 676 St Clair Street, 14th floor, Chicago, Illinois 60611-2951, USA.
Albert J BredenoordAcademic Medical Centre, Department of Gastroenterology and Hepatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Mark FoxAbdominal Center: Gastroenterology, St. Claraspital, Basel, Switzerland and Clinic for Gastroenterology & Hepatology, University Hospital Zürich, Zürich, Switzerland.
C Prakash GyawaliWashington University, Division of Gastroenterology, 660 S. Euclid Ave, Campus BOX 8124, St. Louis, Missouri 63110, USA.
Sabine RomanDigestive Physiology, Hospices Civils de Lyon and Lyon I university Edouard Herriot Hospital, Pavillon L, 5 place d'Arsonval, 69437 Lyon cedex 03, France.
André J P M SmoutAcademic Medical Centre, Department of Gastroenterology and Hepatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
John E PandolfinoNorthwestern University, Feinberg School of Medicine, Department of Medicine, 676 St Clair Street, 14th floor, Chicago, Illinois 60611-2951, USA.
International Working Group for Disorders of Gastrointestinal Motility and Function
Northwestern University · USUniversité Claude Bernard Lyon 1 · FRAmsterdam UMC Location University of Amsterdam · NLWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-resolution manometry (HRM) and new analysis algorithms, summarized in the Chicago Classification, have led to a restructured classification of oesophageal motility disorders. This advance has led to increased detection of clinically relevant disorders, in particular achalasia. It has become apparent that the cardinal feature of achalasia - impaired lower oesophageal sphincter (LES) relaxation - can occur in several disease phenotypes: without peristalsis (type I), with pan-oesophageal pressurization (type II), with premature (spastic) distal oesophageal contractions (type III), or with preserved peristalsis (outlet obstruction). Furthermore, no manometric pattern is perfectly sensitive or specific for achalasia caused by a myenteric plexopathy, and there is no biomarker for this pathology. Consequently, physiological testing reveals other syndromes not meeting achalasia criteria that also benefit from therapies formerly reserved for achalasia. These findings have become particularly relevant with the development of a minimally invasive technique for performing a long oesophageal myotomy, the per-oral endoscopic myotomy (POEM). Optimal management is to render treatment in a phenotype-specific manner; that is, POEM calibrated to patient-specific physiology for spastic achalasia and the spastic disorders, and more conservative strategies such as pneumatic dilation for the disorders limited to the LES. This Consensus Statement examines the effect of HRM on our understanding of oesophageal motility disorders, with a focus on the diagnosis, epidemiology and management of achalasia and achalasia-like syndromes.

Indexed as

ManometryEsophageal AchalasiaHumans

Identifiers

PMID28951579
OpenAlexW2759993710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.