Evidence map›Paper›PMID 28951554›Full record

ArticleScientific reports2017

Endocytosis and lysosomal degradation of GluA2/3 AMPARs in response to oxygen/glucose deprivation in hippocampal but not cortical neurons.

Zsombor Koszegi, Maria Fiuza, Jonathan G Hanley

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. CaThe Journal of physiology · 2021
    Article
  13. Review
  14. Review
  15. Article
  16. Mechanisms of AMPA Receptor Endosomal Sorting.Frontiers in molecular neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zsombor KoszegiCentre for Synaptic Plasticity and School of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
Maria FiuzaCentre for Synaptic Plasticity and School of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol, BS8 1TD, UK.
Jonathan G HanleyCentre for Synaptic Plasticity and School of Biochemistry, Biomedical Sciences Building, University of Bristol, University Walk, Bristol, BS8 1TD, UK. jon.hanley@bristol.ac.uk.
University of Bristol · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/L011131/1
6 · The paper itself

Abstract

Global cerebral ischemia results in oxygen and glucose deprivation (OGD) and consequent delayed cell death of vulnerable neurons, with hippocampal CA1 neurons more vulnerable than cortical neurons. Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/GluA3, and the presence of GluA2 renders AMPARs Ca

Indexed as

Adaptor Protein Complex 2AnimalsApoptosisBrain IschemiaCA1 Region, HippocampalCarrier ProteinsCells, CulturedCytoskeletal ProteinsEndocytosisGlucoseLysosomesNeuronsNuclear ProteinsOxygenPrimary Cell CultureProteolysisAdaptor Protein Complex 2Carrier ProteinsCytoskeletal ProteinsGlucoseglutamate receptor ionotropic, AMPA 2glutamate receptor ionotropic, AMPA 3Nuclear ProteinsOxygenPICK1 protein, ratReceptors, AMPA

Identifiers

PMID28951554
PMCPMC5614987
OpenAlexW2754156610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.